Contemp Clin Trials

Age-related Macular Degeneration (AMD) is the leading cause of irreversible and predictable blindness among older adults with serious physical and mental health consequences. Visual impairment is associated with negative future outlook and depression and has serious consequences for older adults' quality of life and, by way of depression, on long-term survival. Psychosocial interventions have the potential to alleviate and prevent depression symptoms among older AMD patients.|We describe the protocol of the Macular Degeneration and Aging Study, a randomized clinical trial of a psychosocial Preventive Problem-Solving Intervention. The intervention is aimed at enhancing well-being and future planning among older adults with macular degeneration by increasing preparation for future care.|Adequate randomization and therapeutic fidelity were achieved. Current retention rates were acceptable, given the vulnerability of the population. Acceptability (adherence and satisfaction) was high.|Given the high public health significance and impact on quality of life among older adults with vision loss, this protocol contributes a valid test of a promising intervention for maintaining mental and physical health in this population.R01 AG032032/AG/NIA NIH HHS/United StatesR01 AG032032/AG/NIA NIH HHS/United StatesR49 CE002093/CE/NCIPC CDC HHS/United StatesR49 CE002093/CE/NCIPC CDC HHS/United StatesT32 MH018911/MH/NIMH NIH HHS/United StatesT32 MH020061/MH/NIMH NIH HHS/United StatesT32 MH020061/MH/NIMH NIH HHS/United StatesT32 MH073452/MH/NIMH NIH HHS/United States2016-05-01T00:00:00Z25812482PMC445012