Add to ORKGThe pandemic threat posed by emerging zoonotic influenza A viruses necessitates development of antiviral agents effective against various antigenic subtypes. Human monoclonal antibody (hMAb) targeting the hemagglutinin (HA) stalk offers a promising approach to control influenza virus infections. Here, we investigated the ability of the hMAb 81.39a to inhibit in vitro replication of human and zoonotic viruses, representing 16 HA subtypes. The majority of viruses were effectively neutralized by 81.39a at a 50% effective concentration (EC|) of <0.01 to 4.9 \u3bcg/ml. Among group 2 HA viruses tested, a single A(H7N9) virus was not neutralized at 50 \u3bcg/ml; it contained HA|-Asp19Gly, an amino acid position previously associated with resistanc...
Seasonal epidemics caused by influenza A viruses (IAV) result in an estimated 290,000- 650,000 death...
Most neutralizing antibodies elicited during influenza virus infection or vaccination target immunod...
The emergence of A(H7N9) virus strains with resistance to neuraminidase (NA) inhibitors highlights a...
Zoonotic A(H7N9) avian influenza viruses emerged in China in 2013 and continue to be a threat to hum...
Influenza viruses are among the most important human pathogens and are responsible for annual epidem...
Background: The urgent medical need for innovative approaches to control influenza is emphasized by ...
The interest in broad-range anti-influenza A monoclonal antibodies (mAbs) has recently been strength...
SummaryInfluenza virus remains a threat because of its ability to evade vaccine-induced immune respo...
Background: The hemagglutinin (HA) glycoprotein is the principal target of protective humoral immune...
The influenza A virus rapidly mutates to escape from antibodies. Here, we isolated and characterized...
AbstractAvian influenza H5, H7 and H9 viruses top the World Health Organization's (WHO) list of subt...
The interest in broad-range anti-influenza A monoclonal antibodies (mAbs) has recently been strength...
Influenza virus evades host immunity through antigenic drift and shift, and continues to circulate i...
Influenza virus is to date a major threat for humans, causing annual epidemics and sporadic pandemic...
Seasonal influenza viruses are a major cause of human disease worldwide. Most neutralizing antibodie...
Seasonal epidemics caused by influenza A viruses (IAV) result in an estimated 290,000- 650,000 death...
Most neutralizing antibodies elicited during influenza virus infection or vaccination target immunod...
The emergence of A(H7N9) virus strains with resistance to neuraminidase (NA) inhibitors highlights a...
Zoonotic A(H7N9) avian influenza viruses emerged in China in 2013 and continue to be a threat to hum...
Influenza viruses are among the most important human pathogens and are responsible for annual epidem...
Background: The urgent medical need for innovative approaches to control influenza is emphasized by ...
The interest in broad-range anti-influenza A monoclonal antibodies (mAbs) has recently been strength...
SummaryInfluenza virus remains a threat because of its ability to evade vaccine-induced immune respo...
Background: The hemagglutinin (HA) glycoprotein is the principal target of protective humoral immune...
The influenza A virus rapidly mutates to escape from antibodies. Here, we isolated and characterized...
AbstractAvian influenza H5, H7 and H9 viruses top the World Health Organization's (WHO) list of subt...
The interest in broad-range anti-influenza A monoclonal antibodies (mAbs) has recently been strength...
Influenza virus evades host immunity through antigenic drift and shift, and continues to circulate i...
Influenza virus is to date a major threat for humans, causing annual epidemics and sporadic pandemic...
Seasonal influenza viruses are a major cause of human disease worldwide. Most neutralizing antibodie...
Seasonal epidemics caused by influenza A viruses (IAV) result in an estimated 290,000- 650,000 death...
Most neutralizing antibodies elicited during influenza virus infection or vaccination target immunod...
The emergence of A(H7N9) virus strains with resistance to neuraminidase (NA) inhibitors highlights a...