The objectives of this study were to determine if global DNA methylation, as reflected in LINE-1 and Alu elements, is associated with telomere length and whether it modifies the rate of telomeric change. A repeated-measures longitudinal study was performed with a panel of 87 boilermaker subjects. The follow-up period was 29 months. LINE-1 and Alu methylation was determined using pyrosequencing. Leukocyte relative telomere length was assessed via real-time qPCR. Linear-mixed models were used to estimate the association between DNA methylation and telomere length. A structural equation model (SEM) was used to explore the hypothesized relationship between DNA methylation, proxies of particulate matter exposure, and telomere length at baseline....
DNA methylation exhibits a gradual genome-wide decrease in association with aging and the rate of de...
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its und...
Human telomeres can be maintained by the enzyme telomerase, which catalyses the addition of telomere...
In humans, leukocyte telomere length (LTL) is positively correlated with lifespan, and shorter LTL i...
Telomere length, a biomarker of aging and age-related diseases, exhibits wide variation between indi...
Telomere length (TL) is associated with several aging-related diseases. Here, we present a DNA methy...
Telomere length is associated with age-related diseases and is highly heritable. It is unclear, howe...
The frequency of chromosomal aberrations in peripheral blood predicts a probable cancer risk. The in...
Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronologi...
Background: DNA hypomethylation of long interspersed nuclear elements-1 (LINEs-1) occurs during carc...
The average length of telomere repeats (TL) declines with age and is considered to be a marker of bi...
Telomeres are tandem repeats of TTAGGG at the end of eukaryotic chromosomes. Telomeres play a key ro...
Background: Altered DNA methylation has been associated with various diseases. Objective: We evaluat...
BACKGROUND: Altered patterns of gene expression mediate the effects of particulate matter (PM) on hu...
Telomeres are complex nucleotide sequences that cap the end of chromosomes from degradation, unwante...
DNA methylation exhibits a gradual genome-wide decrease in association with aging and the rate of de...
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its und...
Human telomeres can be maintained by the enzyme telomerase, which catalyses the addition of telomere...
In humans, leukocyte telomere length (LTL) is positively correlated with lifespan, and shorter LTL i...
Telomere length, a biomarker of aging and age-related diseases, exhibits wide variation between indi...
Telomere length (TL) is associated with several aging-related diseases. Here, we present a DNA methy...
Telomere length is associated with age-related diseases and is highly heritable. It is unclear, howe...
The frequency of chromosomal aberrations in peripheral blood predicts a probable cancer risk. The in...
Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronologi...
Background: DNA hypomethylation of long interspersed nuclear elements-1 (LINEs-1) occurs during carc...
The average length of telomere repeats (TL) declines with age and is considered to be a marker of bi...
Telomeres are tandem repeats of TTAGGG at the end of eukaryotic chromosomes. Telomeres play a key ro...
Background: Altered DNA methylation has been associated with various diseases. Objective: We evaluat...
BACKGROUND: Altered patterns of gene expression mediate the effects of particulate matter (PM) on hu...
Telomeres are complex nucleotide sequences that cap the end of chromosomes from degradation, unwante...
DNA methylation exhibits a gradual genome-wide decrease in association with aging and the rate of de...
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its und...
Human telomeres can be maintained by the enzyme telomerase, which catalyses the addition of telomere...