Ann Epidemiol

PurposeThis study assessed medication use and associated costs among 8- and 15-yearold children with autism spectrum disorders (ASD) identified by the South Carolina Autism and Developmental Disabilities Monitoring (SCADDM) Network.MethodsAll Medicaid-eligible SCADDM-identified children with ASD from surveillance years 2006 and 2007 were included (n=263). Children were classified as ASD cases when documented behaviors consistent with the DSM-IV-TR criteria for autistic disorder, Asperger disorder, or pervasive developmental disorder- not otherwise specified (PDD-NOS) were present in health and education evaluation records. Medication and cost data were obtained by linking population-based and Medicaid data.ResultsAll 263 SCADDM-identified children had Medicaid data available; 56% (n=147) had a prescription of any type, 40% (n=105) used psychotropic medication, and 20% (n=52) used multiple psychotropic classes over the study period. Common combinations were (1) attention deficit hyperactivity disorder (ADHD) medications and an antihypertensive, antidepressant or antipsychotic; and (2) antidepressants and an antipsychotic. Multiple psychotropic classes were more common among older children. Both the overall distribution of the number of prescription claims and medication costs varied significantly by age.ConclusionsResults confirm that medication use in ASD, alone or in combination, is common, costly, and may increase with age.20122013-01-01T00:00:00ZCDC-RFA-DD06-601/DD/NCBDD CDC HHS/United StatesUL1 TR000062/TR/NCATS NIH HHS/United StatesUL1 RR029882-03/RR/NCRR NIH HHS/United StatesUL1 RR029882/RR/NCRR NIH HHS/United StatesTL1 RR029881-01/RR/NCRR NIH HHS/United StatesTL1 RR029881/RR/NCRR NIH HHS/United StatesTL1RR029881/RR/NCRR NIH HHS/United States22153288PMC324081