Add to ORKGObesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity.T32 DK101019/DK/NIDDK NIH HHS/United ...
Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic...
The gut microbiota has emerged as an integral factor that impacts host metabolism and has been sugge...
SummaryWe have investigated the interrelationship between diet, gut microbial ecology, and energy ba...
Scope: A recent study revealed that the accumulation of gut microbiota-produced acetate (GMPA) led t...
The role of the intestinal microbiota and microbial metabolites in the maintenance of host health an...
The interplay of gut microbiota, host metabolism, and metabolic health has gained increased attentio...
Obesity, insulin resistance and associated metabolic disorders are reaching epidemic proportions wor...
Increased intake of dietary carbohydrate that is fermented in the colon by the microbiota has been r...
The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, ...
Obesity and its complications—including type 2 diabetes, cardiovascular disease, and certain cancers...
Objective: Emerging preclinical evidence has shown that the bidirectional signaling between the gast...
SCOPE: To examine the potential relationship among gene expression markers of adipose tissue brownin...
Gut microbiota has recently been proposed as a crucial environmental factor in the development of me...
Obesity, diabetes and consequently atherosclerotic vascular disease have become major health and pub...
Purpose of reviewTo highlight recent research findings on effects of the short-chain fatty acid acet...
Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic...
The gut microbiota has emerged as an integral factor that impacts host metabolism and has been sugge...
SummaryWe have investigated the interrelationship between diet, gut microbial ecology, and energy ba...
Scope: A recent study revealed that the accumulation of gut microbiota-produced acetate (GMPA) led t...
The role of the intestinal microbiota and microbial metabolites in the maintenance of host health an...
The interplay of gut microbiota, host metabolism, and metabolic health has gained increased attentio...
Obesity, insulin resistance and associated metabolic disorders are reaching epidemic proportions wor...
Increased intake of dietary carbohydrate that is fermented in the colon by the microbiota has been r...
The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, ...
Obesity and its complications—including type 2 diabetes, cardiovascular disease, and certain cancers...
Objective: Emerging preclinical evidence has shown that the bidirectional signaling between the gast...
SCOPE: To examine the potential relationship among gene expression markers of adipose tissue brownin...
Gut microbiota has recently been proposed as a crucial environmental factor in the development of me...
Obesity, diabetes and consequently atherosclerotic vascular disease have become major health and pub...
Purpose of reviewTo highlight recent research findings on effects of the short-chain fatty acid acet...
Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic...
The gut microbiota has emerged as an integral factor that impacts host metabolism and has been sugge...
SummaryWe have investigated the interrelationship between diet, gut microbial ecology, and energy ba...