Add to ORKGMutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). Here, we investigate the function of Pten in cortical GABAergic neurons using conditional mutagenesis in mice. Loss of Pten results in a preferential loss of SST(+) interneurons, which increases the ratio of parvalbumin/somatostatin (PV/SST) interneurons, ectopic PV(+) projections in layer I, and inhibition onto glutamatergic cortical neurons. Pten mutant mice exhibit deficits in social behavior and changes in electroencephalogram (EEG) power. Using medial ganglionic eminence (MGE) transplantation, we test for cell-autonomous functional differences between human PTEN wild-type (WT) and ASD alleles. The PTEN ASD alleles are hypomorphic in regulating ...
In a comprehensive set of experiments in this issue of Neuron, Kwon et al. demonstrate that conditio...
While cognitive deficits have been described in the heterozygous Pten (+/-) KO mouse model of autism...
Germline mutations in PTEN, which encodes a widely expressed phosphatase, was mapped to 10q23 and id...
SummaryMutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). ...
SummaryMutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). ...
Mutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). Here, w...
Mutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). Here, w...
SummaryCNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number,...
PTEN Hamartoma Tumor Syndrome (PHTS) is an autosomal-dominant genetic condition underlying a subset ...
Autism spectrum disorder (ASD) is a neurodevelopmental condition with a clear, but heterogeneous, ge...
PTEN is a tumor suppressor associated with an inherited cancer syndrome and an important regulator o...
Autism spectrum disorder (ASD) is a neurodevelopmental condition with a clear, but heterogeneous, ge...
PTEN Hamartoma Tumor Syndrome (PHTS) is an autosomal-dominant genetic condition underlying a subset ...
Germline mutations in PTEN, which encodes a widely expressed phosphatase, was mapped to 10q23 and id...
ASD is a prevalent neurodevelopmental disorder characterized by social impairments and repetitive be...
In a comprehensive set of experiments in this issue of Neuron, Kwon et al. demonstrate that conditio...
While cognitive deficits have been described in the heterozygous Pten (+/-) KO mouse model of autism...
Germline mutations in PTEN, which encodes a widely expressed phosphatase, was mapped to 10q23 and id...
SummaryMutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). ...
SummaryMutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). ...
Mutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). Here, w...
Mutations in the phosphatase PTEN are strongly implicated in autism spectrum disorder (ASD). Here, w...
SummaryCNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number,...
PTEN Hamartoma Tumor Syndrome (PHTS) is an autosomal-dominant genetic condition underlying a subset ...
Autism spectrum disorder (ASD) is a neurodevelopmental condition with a clear, but heterogeneous, ge...
PTEN is a tumor suppressor associated with an inherited cancer syndrome and an important regulator o...
Autism spectrum disorder (ASD) is a neurodevelopmental condition with a clear, but heterogeneous, ge...
PTEN Hamartoma Tumor Syndrome (PHTS) is an autosomal-dominant genetic condition underlying a subset ...
Germline mutations in PTEN, which encodes a widely expressed phosphatase, was mapped to 10q23 and id...
ASD is a prevalent neurodevelopmental disorder characterized by social impairments and repetitive be...
In a comprehensive set of experiments in this issue of Neuron, Kwon et al. demonstrate that conditio...
While cognitive deficits have been described in the heterozygous Pten (+/-) KO mouse model of autism...
Germline mutations in PTEN, which encodes a widely expressed phosphatase, was mapped to 10q23 and id...