Environ Health Perspect

BackgroundChildhood respiratory allergies, which contribute to missed school days and other activity limitations, have increased in recent years, possibly due to environmental factors.ObjectiveIn this study we examined whether air pollutants are associated with childhood respiratory allergies in the United States.MethodsFor the approximately 70,000 children from the 1999\u20132005 National Health Interview Survey eligible for this study, we assigned between 40,000 and 60,000 ambient pollution monitoring data from the U.S. Environmental Protection Agency, depending on the pollutant. We used monitors within 20 miles of the child\u2019s residential block group. We used logistic regression models, fit with methods for complex surveys, to examine the associations between the reporting of respiratory allergy or hay fever and annual average exposure to particulate matter 64 2.5 \u3bcm in diameter (PM2.5), PM 64 10 \u3bcm in diameter, sulfur dioxide, and nitrogen dioxide and summer exposure to ozone, controlling for demographic and geographic factors.ResultsIncreased respiratory allergy/hay fever was associated with increased summer O3 levels [adjusted odds ratio (AOR) per 10 ppb = 1.20; 95% confidence interval (CI), 1.15\u20131.26] and increased PM2.5 (AOR per 10 \u3bcg/m3 = 1.23; 95% CI, 1.10\u20131.38). These associations persisted after stratification by urban\u2013rural status, inclusion of multiple pollutants, and definition of exposures by differing exposure radii. No associations between the other pollutants and the reporting respiratory allergy/hay fever were apparent.ConclusionsThese results provide evidence of adverse health for children living in areas with chronic exposure to higher levels of O3 and PM2.5 compared with children with lower exposures.2008891