Add to ORKGCaspases, aspartate-specific cysteine proteases, have fate-determining roles in many cellular processes including apoptosis, differentiation, neuronal remodeling, and inflammation (for review, see Yuan & Kroemer, 2010). There are a dozen caspases in humans alone, yet their individual contributions toward these phenotypes are not well understood. Thus, there has been considerable interest in activating individual caspases or using their activity to drive these processes in cells and animals. We envision that such experimental control of caspase activity can not only afford novel insights into fundamental biological problems but may also enable new models for disease and suggest possible routes to therapeutic intervention. In particular, loca...
Since molecular cloning of the C. elegans ced-3 gene revealed its homology with mammalian IL-1β-con...
AbstractIntense research into the signaling pathways of apoptosis has revealed a dominant role for p...
Abstract. Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their act...
Caspases, aspartate-specific cysteine proteases, have fate-determining roles in many cellular proces...
SummaryApoptosis is a conserved cellular pathway that results in the activation of cysteine-aspartyl...
BackgroundThe caspase-mediated proteolysis of many cellular proteins is a critical event during prog...
Apoptosis, or programmed cell death, plays an integral role in normal tissue development, killing ce...
Caspases are the cysteine proteases that govern apoptotic cell death. The regulation of these enzyme...
SummaryCaspases are proteases with an active-site cysteine and aspartate specificity in their substr...
It has become increasingly clear that caspases, far from being merely cell death effectors, have a m...
Caspases are a family of endoproteases that provide critical links in cell regulatory networks contr...
SummaryAlthough significant efforts have been made to understand the mechanisms of caspase activatio...
AbstractRecent studies have established that members of the caspase protease family are essential co...
Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their activation is...
AbstractPrevious studies have shown that Apaf-1 and caspase-9 in the presence of cytochrome c and dA...
Since molecular cloning of the C. elegans ced-3 gene revealed its homology with mammalian IL-1β-con...
AbstractIntense research into the signaling pathways of apoptosis has revealed a dominant role for p...
Abstract. Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their act...
Caspases, aspartate-specific cysteine proteases, have fate-determining roles in many cellular proces...
SummaryApoptosis is a conserved cellular pathway that results in the activation of cysteine-aspartyl...
BackgroundThe caspase-mediated proteolysis of many cellular proteins is a critical event during prog...
Apoptosis, or programmed cell death, plays an integral role in normal tissue development, killing ce...
Caspases are the cysteine proteases that govern apoptotic cell death. The regulation of these enzyme...
SummaryCaspases are proteases with an active-site cysteine and aspartate specificity in their substr...
It has become increasingly clear that caspases, far from being merely cell death effectors, have a m...
Caspases are a family of endoproteases that provide critical links in cell regulatory networks contr...
SummaryAlthough significant efforts have been made to understand the mechanisms of caspase activatio...
AbstractRecent studies have established that members of the caspase protease family are essential co...
Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their activation is...
AbstractPrevious studies have shown that Apaf-1 and caspase-9 in the presence of cytochrome c and dA...
Since molecular cloning of the C. elegans ced-3 gene revealed its homology with mammalian IL-1β-con...
AbstractIntense research into the signaling pathways of apoptosis has revealed a dominant role for p...
Abstract. Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their act...