Add to ORKGEnvironmental factors, including pesticides, have been linked to autism and neurodegeneration risk using retrospective epidemiological studies. Here we sought to prospectively identify chemicals that share transcriptomic signatures with neurological disorders, by exposing mouse cortical neuron-enriched cultures to hundreds of chemicals commonly found in the environment and on food. We find that rotenone, a pesticide associated with Parkinson's disease risk, and certain fungicides, including pyraclostrobin, trifloxystrobin, famoxadone and fenamidone, produce transcriptional changes in vitro that are similar to those seen in brain samples from humans with autism, advanced age and neurodegeneration (Alzheimer's disease and Huntington's disease...
There is credible evidence that environmental factors influence individual risk and/or severity of a...
Multiple observations indicate that environmental and epigenetic factors play an important role in t...
Persistent organic pollutants are of growing concern with regards to neurodevelopment. Polybrominate...
Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk u...
BackgroundAutism spectrum disorders (ASDs) have been increasing in many parts of the world and a por...
Autism spectrum disorder (ASD) is a major public health concern caused by complex genetic and enviro...
Only a small percentage of neurodegenerative diseases like Alzheimer's disease and Parkinson's disea...
Organophosphorus (OP) compounds have been known as the most widely used pesticides during the past h...
Microglia are the primary immune cells of the central nervous system and become activated in respons...
International audienceBackground: A growing body of evidences suggests an association between early ...
Research continues to identify genetic variation, environmental exposures, and their mixtures underl...
Alterations in gut microbiome composition have an emerging role in health and disease including brai...
Background: Autism spectrum disorder (ASD) is a major public health concern caused by complex geneti...
Glufosinate ammonium (GLA) is one of the most widely used herbicides in agriculture. As for almost a...
While a number of genetic mutations are associated with Parkinson's disease (PD), it is also widely ...
There is credible evidence that environmental factors influence individual risk and/or severity of a...
Multiple observations indicate that environmental and epigenetic factors play an important role in t...
Persistent organic pollutants are of growing concern with regards to neurodevelopment. Polybrominate...
Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk u...
BackgroundAutism spectrum disorders (ASDs) have been increasing in many parts of the world and a por...
Autism spectrum disorder (ASD) is a major public health concern caused by complex genetic and enviro...
Only a small percentage of neurodegenerative diseases like Alzheimer's disease and Parkinson's disea...
Organophosphorus (OP) compounds have been known as the most widely used pesticides during the past h...
Microglia are the primary immune cells of the central nervous system and become activated in respons...
International audienceBackground: A growing body of evidences suggests an association between early ...
Research continues to identify genetic variation, environmental exposures, and their mixtures underl...
Alterations in gut microbiome composition have an emerging role in health and disease including brai...
Background: Autism spectrum disorder (ASD) is a major public health concern caused by complex geneti...
Glufosinate ammonium (GLA) is one of the most widely used herbicides in agriculture. As for almost a...
While a number of genetic mutations are associated with Parkinson's disease (PD), it is also widely ...
There is credible evidence that environmental factors influence individual risk and/or severity of a...
Multiple observations indicate that environmental and epigenetic factors play an important role in t...
Persistent organic pollutants are of growing concern with regards to neurodevelopment. Polybrominate...