Malaria has long been a serious problem in the "low country" or coastal plain region of South Carolina, particularly in the Santee River Basin of that State. In studying records collected from this area over the last ten years, it is evident that a clear-cut focus of malaria has existed and continues to exist in the vicinity of the Santee River in Clarendon, Berkeley, and Orangeburg Counties. Furthermore, these studies have indicated that in some sections malaria has increased since the 1941 impoundage of water on the Pinopolis and Santee Basins, and that minor epidemics have occurred during the seasons of 1942 and 1943 in Clarendon County near the Santee Reservoir.Realizing the seriousness of the malaria problem in the area adjacent to the...