Add to ORKGHigh-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major challenge in neuroscience. Here we demonstrate simultaneous functional imaging of neuronal activity at single-neuron resolution in an entire Caenorhabditis elegans and in larval zebrafish brain. Our technique captures the dynamics of spiking neurons in volumes of \ue2\u2c6\ubc700 \uce\ubcm \uc3\u2014 700 \uce\ubcm \uc3\u2014 200 \uce\ubcm at 20 Hz. Its simplicity makes it an attractive tool for high-speed volumetric calcium imaging.1DP1NS087724/DP/NCCDPHP CDC HHS/United States1R01EY023173/EY/NEI NIH HHS/United StatesDP1 NS087724/NS/NINDS NIH HHS/United StatesR01 EY023173/EY/NEI NIH HHS/United States2015-01-01T00:00:00Z24836920PMC410025
Efforts to scale neuroimaging towards the direct visualization of mammalian brain-wide neuronal acti...
Brain is composed of complex neural networks that work in concert to underlie the animal’s cognition...
Fast volumetric microscopy is required to monitor large-scale neural ensembles with high spatio-temp...
High-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major challenge ...
These authors contributed equally to this work. High-speed large-scale 3D imaging of neuronal activi...
A major challenge in neuroscience is to sample large-scale neuronal activity at high speed and resol...
Recording the activity of large populations of neurons is an important step toward understanding the...
Understanding the mechanisms of perception, cognition, and behavior requires instruments that are ca...
Increasing the volumetric imaging speed of light-sheet microscopy will improve its ability to detect...
Neurons and neural networks often extend hundreds of micrometers in three dimensions. Capturing the ...
Progress in modern neuroscience critically depends on our ability to observe the activity of large n...
Significance: Light-field microscopy (LFM) enables fast, light-efficient, volumetric imaging of neur...
In vitro systems mimicking brain regions, brain organoids, are revolutionizing the neuroscience fiel...
Neurons and neural networks often extend hundreds of micrometers in three dimensions. Capturing the ...
Light-field microscopy has emerged as a technique of choice for high-speed volumetric imaging of fas...
Efforts to scale neuroimaging towards the direct visualization of mammalian brain-wide neuronal acti...
Brain is composed of complex neural networks that work in concert to underlie the animal’s cognition...
Fast volumetric microscopy is required to monitor large-scale neural ensembles with high spatio-temp...
High-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major challenge ...
These authors contributed equally to this work. High-speed large-scale 3D imaging of neuronal activi...
A major challenge in neuroscience is to sample large-scale neuronal activity at high speed and resol...
Recording the activity of large populations of neurons is an important step toward understanding the...
Understanding the mechanisms of perception, cognition, and behavior requires instruments that are ca...
Increasing the volumetric imaging speed of light-sheet microscopy will improve its ability to detect...
Neurons and neural networks often extend hundreds of micrometers in three dimensions. Capturing the ...
Progress in modern neuroscience critically depends on our ability to observe the activity of large n...
Significance: Light-field microscopy (LFM) enables fast, light-efficient, volumetric imaging of neur...
In vitro systems mimicking brain regions, brain organoids, are revolutionizing the neuroscience fiel...
Neurons and neural networks often extend hundreds of micrometers in three dimensions. Capturing the ...
Light-field microscopy has emerged as a technique of choice for high-speed volumetric imaging of fas...
Efforts to scale neuroimaging towards the direct visualization of mammalian brain-wide neuronal acti...
Brain is composed of complex neural networks that work in concert to underlie the animal’s cognition...
Fast volumetric microscopy is required to monitor large-scale neural ensembles with high spatio-temp...