The effects of actomyosin disruptors on the mechanical integrity of the avian crystalline lens

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed. Original Publication: Won, G.-J., Fudge, D. S., & Choh, V. (2015, January 27). The effects of actomyosin disruptors on the mechanical integrity of the avian crystalline lens. Molecular Vision, 21, 98-XX. http://www.molvis.org/molvis/v21/98/Actin and myosin within the crystalline lens maintain the structural integrity of lens fiber cells and form a hexagonal lattice cradling the posterior surface of the lens. The actomyosin network was pharmacologically disrupted to examine the effects on lenticular biomechanics and optical quality.This project was generously funded by the Natural Sciences and Engineering Research Council of Canada (V.C. and D.S.F.) and the Canadian Optometric Education Trust Fund (G.W.)