Atypical carcinoid of the larynx - case report

Neuroendokrini karcinomi izuzetno su rijetki u podrucju grkljana, a sukladno preporuci Svjetske zdravstvene organizacije podijeljeni su u tri grupe: tipicni karcinoid – dobrodiferencirani neuroendokrini karcinom, atipicni karcinoid – umjereno diferencirani neuroendokrini karcinom i sitno stanicni neuroendokrini karcinom – slabo iferencirani neuroendokrini karcinom. Važno je razlikovati svaki od ovih tumora zbog drugacijeg nacina lijecenja i prognoze. Atipicni karcinoid je najcešci oblik ove vrste tumora u grkljanu. U pravilu je supragloticne lokalizacije s tendecijom lokalne invazije i metastaziranja. Autori prikazuju slucaj atipicnog karcinoida lokaliziranog na lijevom ariepigloticnom naboru kod 71- godišnjeg muškarca, patohistološku i imunohistokemijsku obradu: citokeratin, epitelijalni membranski antigen, kromogranin A i sinaptofizin. Tretman je ukljucio transoralnu endoskopsku reskeciju tumora. Pacijent je nakon petogodišnjeg pracenja urednog lokalnog nalaza.Neuroendocrine carcinomas are very rare in the area of the larynx, and, according to the World Health Organisation, they are divided into three groups: typical carcinoid – well differentiated euroendocrine carcinoma, atypical carcinoid tumour – moderately differentiated neuroendocrine carcinoma, and a small cell neuroendocrine arcinoma – poorly differentiated neuroendocrine carcinoma. It is very important to differ the mentioned types of tumours because of different types of treatment and prognoses. The atypical carcinoid is the most common type of the larynx tumours and, as a rule, it is supraglottis located with a tendency to local invasion and metastases. The authors show a case of atypical carcinoid localised on the left ryepiglottic fold of a 71-year-old male, pathohistological and mmunohistochemical diagnostic analysis: cytokeratin, epithelial embrane antigen, chromogranin A, synaptophysin. The treatment includes transoral endoscopic resection of the tumour. The patient has been observed for five years and his findings are normal