Hemodynamic Differences in Sevoflurane Versus Propofol Anesthesia

The aim of the study was to compare the effect of sevoflurane and propofol anesthesia on myocardial contractility during laparotomic cholecystectomy using transesophageal echo-Doppler. In the study, 40 patients were randomized into two groups, depending on whether they received sevoflurane or propofol anesthesia. Heart rate, cardiac index, stroke volume, left ventricular ejection time and acceleration were measured 10 minutes after induction of anesthesia, 1 minute and 25 minutes after incision. The results were analyzed using paired t-test and ANOVA. Significantly lower values were found for all parameters after the initial measurement (p<0.05). In the sevoflurane group, stroke volume decreased from 666.2 ml/beat to 656.4 ml/beat and to 635.6 ml/beat 1 minute and 25 minutes after incision respectively. In the propofol group changes were from 64 ml/beat to 5810.5 ml/beat to 588.6 ml/beat. Stroke volume was significantly higher in the sevoflurane than in the propofol group (p