Photodynamic Therapy Combined with Intravitreal Bevacizumab (Avastin) in Treatment of Choroidal Neovascularization Secondary to Age-Related Macular Degeneration

To evaluate photodynamic therapy with verteporfin combined with intravitreal bevacizumab in minimally classic and occult choroidal neovascularization secondary to age-related macular degeneration. 46 eyes of 46 patients (mean age 74.5) included in this prospective, noncomparative, interventional case series. Median follow-up was 24 weeks (12–36). Verteporfin photodynamic therapy (PDT) was followed by 0.05 mL (1.25 mg) of bevacizumab injected intravitreally within 24 hours and again after 6 weeks. Whole procedure was repeated in 3-month intervals in case of leakage. Visual acuity (VA) improved in majority of patients (baseline VA 1.041 log MAR) by mean increase of 1.45 lines (last follow-up) (p=0.001). Central foveal thickness (CFT) and total macular volume (TMV) decreased by 53 μm (p=0.03) and 1.04 mm3 (p