Obesity paradox among type 2 diabetes: Link between obesity and chronic kidney disease

[[abstract]]Background: Obesity has been linked to chronic kidney disease (CKD) in the general population, but little is known about the association of obesity and changes in obesity status with CKD in the diabetic population. Methods: A cohort of 1199 Taiwanese adults with type 2 diabetes was followed up from baseline (2003–2005) to 2010. We evaluated BMI at baseline and repeated in 2008, 2009, and 2010 as a continuous term and a category according to the World Health Organisation (WHO) cut-off points for Asian populations (normal: +5 to +10, and >+10%). CKD was defined as estimated glomerular filtration rate (eGFR) 10% had a significant increased risk for CKD (OR = 2.79, 95% CI = 1.49–5.21, p = 0.001) compared with those who remained within a ±5% range of their baseline BMI. Conclusions: In this large cohort of type 2 diabetes, patients who had a high BMI or gained weight over a 7-years follow-up period had a significant increased risk of CKD