Statin use and the risk of gallstone disease: A population-based case-control study

[[abstract]]Objective: The aim of this study was to investigate whether the use of statinswas associated with a decreased risk of gallstone disease.Methods: We conducted a population-based case--control study in Taiwan.Cases consisted of all patients who were aged 50 years and older and had afirst-time diagnosis of gallstone disease or cholecystectomy for the periodbetween 2005 and 2009. The controls were matched to cases by age, sexand index date. Adjusted odds ratios (ORs) and 95% confidence intervals(CIs) were estimated by using multiple logistic regression.Results: We examined 1014 gallstone disease cases and 1014 controls. Theunadjusted ORs for any statin prescription was 1.06 (95% CI 0.86 to 1.29),and the adjusted OR was 1.14 (95% CI 0.90 to 1.43). Compared with no useof statins, the adjusted ORs were 1.05 (95% CI 0.72 to 1.54) for the group hav-ing been prescribed statins with cumulative defined daily doses (DDDs) below41.53, 1.12 (95% CI 0.84 to 1.50) for the group with cumulative dose between41.54 and 334.81 DDD, and 1.30 (95% CI 0.86 to 1.95) for the group withcumulative statin use of 334.81 DDDs or more.Conclusions: This study does not provide support for a beneficial associationbetween usage of statin and gallstone disease