Surveillance of antimicrobial susceptibility of Escherichia coli isolates during the period of 2003-2007. in Primorsko-Goranska County

SAŽETAK. Cilj: Escherichia coli (E. coli) uzrokuje i do 80% izvanbolničkih infekcija mokraćnog sustava. Zbog nužnosti empirijske terapije infekcija mokraćnog sustava došlo je do pojave smanjene osjetljivosti uzročnika na antibiotike. Cilj ovog rada bio je istražiti kretanje osjetljivosti izolata E. coli u petogodišnjem razdoblju na području Primorsko-goranske županije. Metode: U Laboratoriju za urogenitalne infekcije Mikrobiološkog odjela Nastavnog zavoda za javno zdravstvo Primorsko-goranske županije od 2003. od 2007. godine izolirano je 18.869 sojeva E. coli. Disk difuzijskom metodom ispitana je osjetljivost na amoksicilin, ko-trimoksazol (trimetoprim-sulfametoksazol), amoksicilin-klavulonsku kiselinu, norfloksacin, cefalotin, cefuroksim, ceftibuten i gentamicin. Rezultati: Testirani sojevi pokazali su najveći stupanj otpornosti prema amoksicilinu (37 – 41%) i ko-trimoksazolu (19 – 30%). Otpornost prema svim ostalim antibioticima bila je niža od 10,26%. Zaključak: U razdoblju od 2003. do 2007. godine osjetljivost izolata E. coli s područja Primorsko-goranske županije na istraživane antibiotike nije se bitnije mijenjala.ABSTRACT. Aim: Escherichia coli (E.coli) is responsible for up to 80% of community-acquired urinary tract infections. As the onset of treatment of urinary tract infections is mostly empirical, the antibiotic resistance of uropathogens has become an increasing problem. The aim of the present study was to investigate the movement of antimicrobial susceptibility of E.coli strains isolated during a five year period in Primorsko-Goranska County. Methods: During the years 2003-2007 in the Laboratory for urogenital infections, Department of Microbiology of the Teaching Institute of Public Health of Primorsko-Goranska County, the number of E.coli isolates was 18.869. Susceptibility to amoxicillin, co-trimoxazole (trimethoprim – sulfamethoxazole), amoxicillin-clavulanic acid, norfloxacin, cephalothin, cefuroxime, ceftibuten and gentamicin was tested using the disk diffusion method. Results: Analysed E.coli strains demonstrated the highest resistance rate to amoxicillin (37% – 41%), followed by co-trimoxasole (19% – 30%). Resistance of E.coli isolated to all other antibiotics was lower than 10,26%. Conclusions: During the period 2003-2007 the antimicrobial susceptibility of E.coli isolates from Primorsko-Goranska County remained almost unchanged