[[abstract]]The switch between latency and lytic cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) is accompanied by specific alterations of histone codes. Recently, comprehensive analysis of histone modifications of KSHV showed the deposition of H3K27me3 across KSHV genome with two specific regions occupied by the heterochromatin marker H3K9me3. Here, we show that knockdown of JMJD2A, an H3K9me3 demethylase, attenuates viral titers, whereas its overexpression increases KSHV reactivation. JMJD2A is localized in regions of latent viral chromosomes that are deficient in the H3K9me3 mark, indicating that JMJD2A may be responsible for the low level of this mark on viral chromatin. The presence of JMJD2A on the latent genome maintains H3K9...
Herpesvirus latency is generally thought to be governed by epigenetic modifications, but the dynamic...
ABSTRACT The early period of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection involves the d...
Kaposi’s sarcoma-associated herpesvirus (KSHV) belongs to the gamma herpesvirus family and is the ca...
[[abstract]]The switch between latency and lytic cycle of Kaposi's sarcoma-associated herpesvirus (K...
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of three human malignancies, t...
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiologic agent of three human malignancies, t...
1 Histone demethylase JMJD2A regulates KSHV replication and is targeted by a viral transcriptional f...
Establishment of viral latency is not only essential for lifelong Kaposi's sarcoma-associated herpes...
Small ubiquitin-like modifier (SUMO) modification of chromatin has profound effects on transcription...
Human Cytomegalovirus (hCMV) infects a broad range of the population and establishes life-long laten...
Human Cytomegalovirus (hCMV) infects a broad range of the population and establishes life-long laten...
<div><p>Human Cytomegalovirus (hCMV) infects a broad range of the population and establishes life-lo...
Bivalent histone modifications are defined as repressive and activating epigenetic marks that simult...
Kaposi’s sarcoma-associated herpesvirus is an oncogenic γ-herpesvirus that causes latent infection i...
<div><p>Kaposi’s sarcoma associated herpesvirus (KSHV) persists in a highly-ordered chromatin struct...
Herpesvirus latency is generally thought to be governed by epigenetic modifications, but the dynamic...
ABSTRACT The early period of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection involves the d...
Kaposi’s sarcoma-associated herpesvirus (KSHV) belongs to the gamma herpesvirus family and is the ca...
[[abstract]]The switch between latency and lytic cycle of Kaposi's sarcoma-associated herpesvirus (K...
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of three human malignancies, t...
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiologic agent of three human malignancies, t...
1 Histone demethylase JMJD2A regulates KSHV replication and is targeted by a viral transcriptional f...
Establishment of viral latency is not only essential for lifelong Kaposi's sarcoma-associated herpes...
Small ubiquitin-like modifier (SUMO) modification of chromatin has profound effects on transcription...
Human Cytomegalovirus (hCMV) infects a broad range of the population and establishes life-long laten...
Human Cytomegalovirus (hCMV) infects a broad range of the population and establishes life-long laten...
<div><p>Human Cytomegalovirus (hCMV) infects a broad range of the population and establishes life-lo...
Bivalent histone modifications are defined as repressive and activating epigenetic marks that simult...
Kaposi’s sarcoma-associated herpesvirus is an oncogenic γ-herpesvirus that causes latent infection i...
<div><p>Kaposi’s sarcoma associated herpesvirus (KSHV) persists in a highly-ordered chromatin struct...
Herpesvirus latency is generally thought to be governed by epigenetic modifications, but the dynamic...
ABSTRACT The early period of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection involves the d...
Kaposi’s sarcoma-associated herpesvirus (KSHV) belongs to the gamma herpesvirus family and is the ca...