[[abstract]]The antitubulin agents taxanes and Vinca alkaloids form the first-line of treatment in clinical oncology for many cancers. The crucial role of microtubules in cell division has made antitubulin agents the focus of research, with sustained efforts to find new agents and to improve the profile of known agents by overcoming multi-drug resistance (MDR) and improving the druggability. The present review updates the medicinal chemistry of antitubulin agents covering the patents and literature published from May 2002 to November 2005. The antitubulin agents have been broadly classified into microtubule-destabilising agents, microtubule-stabilising agents and kinesin-like spindle protein inhibitors. This review provides an insight into ...
International audienceMicrotubules are dynamic filamentous cytoskeletal proteins composed of tubulin...
Anti-tubulin agents constitute a large class of compounds with broad activity both in solid tumors a...
Tubulin targeting agents constitute an important class of anticancer drugs. By acting either as micr...
[[abstract]]The antitubulin agents taxanes and Vinca alkaloids form the first-line of treatment in c...
Microtubules (MTs) play important and diverse roles in eukaryotic cells. Their function and biophysi...
Microtubules (MTs) play important and diverse roles in eukaryotic cells. Their function and biophysi...
Microtubule targeting drugs like taxanes, vinca alkaloids, and epothilones are widely-used and effec...
Microtubule targeting drugs like taxanes, vinca alkaloids, and epothilones are widely-used and effec...
International audienceEven though commercialized anticancer drugs are now produced by pharmaceutical...
Microtubules are important cellular targets for anticancer therapy because of their key role in mito...
International audienceEven though commercialized anticancer drugs are now produced by pharmaceutical...
This review article provides an overview on the current state of research in the area of microtubule...
International audienceMicrotubules are dynamic filamentous cytoskeletal proteins composed of tubulin...
International audienceMicrotubules are dynamic filamentous cytoskeletal proteins composed of tubulin...
Anti-tubulin agents constitute a large class of compounds with broad activity both in solid tumors a...
International audienceMicrotubules are dynamic filamentous cytoskeletal proteins composed of tubulin...
Anti-tubulin agents constitute a large class of compounds with broad activity both in solid tumors a...
Tubulin targeting agents constitute an important class of anticancer drugs. By acting either as micr...
[[abstract]]The antitubulin agents taxanes and Vinca alkaloids form the first-line of treatment in c...
Microtubules (MTs) play important and diverse roles in eukaryotic cells. Their function and biophysi...
Microtubules (MTs) play important and diverse roles in eukaryotic cells. Their function and biophysi...
Microtubule targeting drugs like taxanes, vinca alkaloids, and epothilones are widely-used and effec...
Microtubule targeting drugs like taxanes, vinca alkaloids, and epothilones are widely-used and effec...
International audienceEven though commercialized anticancer drugs are now produced by pharmaceutical...
Microtubules are important cellular targets for anticancer therapy because of their key role in mito...
International audienceEven though commercialized anticancer drugs are now produced by pharmaceutical...
This review article provides an overview on the current state of research in the area of microtubule...
International audienceMicrotubules are dynamic filamentous cytoskeletal proteins composed of tubulin...
International audienceMicrotubules are dynamic filamentous cytoskeletal proteins composed of tubulin...
Anti-tubulin agents constitute a large class of compounds with broad activity both in solid tumors a...
International audienceMicrotubules are dynamic filamentous cytoskeletal proteins composed of tubulin...
Anti-tubulin agents constitute a large class of compounds with broad activity both in solid tumors a...
Tubulin targeting agents constitute an important class of anticancer drugs. By acting either as micr...