Antikonvulzivno djelovanje Schiffovih baza- derivata isatina

Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin 2 exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg-1, showing better activity than the standard drugs phenytoin, carbamazepine and valproic acid. Thus, compound 2 may be chosen as a prototype for development of new anticonvulsants.Schiffove baze N-metil i N-acetil derivata izatina s različitim aromatskim aminima sintetizirane su i ispitane na sposobnost suzbijanja konvulzija uzrokovanih elektrošokom (MES) i subkutanom primjenom metrazola (ScMet). N-metil-5-bromo-3-(p-klorofenilimino) izatin 2 pokazao je nisku neurotoksičnost i jače antikonvulzivno djelovanje nego standardni antikonvulzivi fenitoin, karbamazepin i valproična kiselina. Zbog toga se spoj 2 može smatrati prototipom za razvoj novih antikonvulziva