Infection of host cells by the virus HIV-1 is mediated by the trimeric envelope glycoprotein (Env). During the process, Env transitions from its native state on the surface of the virus into an intermediate state bridging the viral and target cell membranes. Afterwards, Env conforms into a trimer-of-hairpins structure which brings the membranes together and allows them to fuse. The focus of this work was to further our understanding of these two major transitions of Env, both in the context of developing and refining treatment strategies to prevent HIV-1 entry and in the context of understanding viral membrane fusion in greater detail. ^ In the first portion of these studies, fusion inhibitors, which target the gp41 subunits of Env in the...
The human immunodeficiency virus (HIV) envelope glycoprotein (Env), a (gp120/gp41)₃ trimer, is prese...
HIV-1 entry into host cells is mediated by the trimeric envelope glycoprotein (Env). During the fusi...
The HIV-1 envelope (Env) glycoprotein, a trimer of gp120-gp41 heterodimers, relies on conformational...
Infection of host cells by the virus HIV-1 is mediated by the trimeric envelope glycoprotein (Env). ...
Infection by the virus HIV-1 is initiated by interactions between host cell receptors (CD4 and a che...
SummaryThe HIV envelope glycoprotein (Env) trimer undergoes receptor-induced conformational changes ...
The envelope glycoprotein, Env, of human immunodeficiency virus type 1 (HIV-1) mediates viral entry ...
Abstract Enveloped viruses encode specialized fusion proteins which promote the merger of viral and ...
<p>(<b>A</b>) In the native, prefusogenic conformation (PDB ID: 5FYL, [<a href="http://www.plospatho...
HIV-1 Env, a trimer of gp120-gp41 heterodimers, mediates membrane fusion after binding host receptor...
The activation of trimeric HIV-1 envelope glycoprotein (Env) by its binding to the cell surface rece...
AbstractThe current general model of HIV viral entry involves the binding of the trimeric viral enve...
ABSTRACT Primary human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimers [(gp120/gp...
The HIV-1 envelope glycoprotein (Env) is a trimer of gp120-gp41 heterodimers and is essential for vi...
The human immunodeficiency virus (HIV-1) envelope (Env) glycoprotein, a (gp120–gp41)₃ trimer, mediat...
The human immunodeficiency virus (HIV) envelope glycoprotein (Env), a (gp120/gp41)₃ trimer, is prese...
HIV-1 entry into host cells is mediated by the trimeric envelope glycoprotein (Env). During the fusi...
The HIV-1 envelope (Env) glycoprotein, a trimer of gp120-gp41 heterodimers, relies on conformational...
Infection of host cells by the virus HIV-1 is mediated by the trimeric envelope glycoprotein (Env). ...
Infection by the virus HIV-1 is initiated by interactions between host cell receptors (CD4 and a che...
SummaryThe HIV envelope glycoprotein (Env) trimer undergoes receptor-induced conformational changes ...
The envelope glycoprotein, Env, of human immunodeficiency virus type 1 (HIV-1) mediates viral entry ...
Abstract Enveloped viruses encode specialized fusion proteins which promote the merger of viral and ...
<p>(<b>A</b>) In the native, prefusogenic conformation (PDB ID: 5FYL, [<a href="http://www.plospatho...
HIV-1 Env, a trimer of gp120-gp41 heterodimers, mediates membrane fusion after binding host receptor...
The activation of trimeric HIV-1 envelope glycoprotein (Env) by its binding to the cell surface rece...
AbstractThe current general model of HIV viral entry involves the binding of the trimeric viral enve...
ABSTRACT Primary human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimers [(gp120/gp...
The HIV-1 envelope glycoprotein (Env) is a trimer of gp120-gp41 heterodimers and is essential for vi...
The human immunodeficiency virus (HIV-1) envelope (Env) glycoprotein, a (gp120–gp41)₃ trimer, mediat...
The human immunodeficiency virus (HIV) envelope glycoprotein (Env), a (gp120/gp41)₃ trimer, is prese...
HIV-1 entry into host cells is mediated by the trimeric envelope glycoprotein (Env). During the fusi...
The HIV-1 envelope (Env) glycoprotein, a trimer of gp120-gp41 heterodimers, relies on conformational...