Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent
- Franckenberg, Sabine
- Berger, Florian
- Schaerli, Sarah
- Ampanozi, Garyfalia
- Thali, Michael J
DOIAbstract
We present the rare case of a fatal anaphylactic reaction to gadobutrol, a magnetic resonance imaging contrast agent, in a 42-year-old man. The patient underwent elective magnetic resonance imaging for diagnostic clarification of a suspicious finding in the abdomen. The patient had undergone contrast-enhanced computed tomography previously without the occurrence of any adverse effects. Adverse drug reactions in gadobutrol have a very low prevalence of 0.32%-3.5%, with serious adverse drug reactions in <0.1%. There are only a few cases of fatal anaphylactoid reactions to gadolinium-based contrast agents in general. However, if an anaphylactoid reaction occurs, it can present itself with a fulminant course within minutes
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