[[abstract]]A total of 294 edible protein sequences and 5 commercial proteases listed in the BIOPEP database were analyzed in silico. The frequency (A), a parameter in silico described previously, was examined further to calculating the ratio of truncated peptides with Xaa-proline and/or Xaa-alanine to all peptide fragments in a protein hydrolyzed with a protease, using the BIOPEP database. Then the in vitro DPP-IV inhibitory activity was determined using the same 15 protein and protease combinations to evaluate their relationship. The result shows that A values considering the number of Xaa-proline + Xaa-alanine exhibited a strong correlation with in vitro DPP-IV inhibition rates by Pearson’s correlation analysis (r = 0.6993; P < 0.05). Th...
Dipeptidyl peptidase IV (DPPIV, DPP4) is a serine protease that releases N-terminal dipeptides. It i...
A database of potentially biologically active peptide sequences, named BIOPEP (http://www.uwm.edu.pl...
An integrated approach combining liquid chromatography/tandem mass spectrometry (LC-MS/MS) with in s...
<p>Inhibition of dipeptidyl peptidase IV (DPP-IV) may be exploited to maintain the incretin effect d...
Inhibition of dipeptidyl peptidase IV (DPP-IV) may be exploited to maintain the incretin effect duri...
Inhibition of dipeptidyl peptidase IV (DPP-IV) may be exploited to maintain the incretin effect duri...
Molecular docking of a library of all 8000 possible tripeptides to the active site of DPP-IV was use...
BACKGROUND: There has been great interest in determining whether natural products show biological ac...
peer-reviewedBovine α-lactalbumin (α-La) contains numerous dipeptidyl peptidase IV (DPP-IV) inhibito...
Background: There has been great interest in determining whether natural products show biological ac...
Inhibition of the enzyme dipeptidyl-peptidase IV (DPP-IV) is a promising approach for managing hyper...
Dipeptidyl-peptidase IV (DPP-IV) plays an essential role in glucose metabolism by inactivating incre...
Dipeptidyl peptidase IV (DPP-IV) is a new molecular target correlated with the development of type 2...
The conventional approach in bioactive peptides discovery, which includes extensive bioassay-guided ...
Diabetes is a chronic metabolic disorder which leads to high blood sugar levels over a prolonged per...
Dipeptidyl peptidase IV (DPPIV, DPP4) is a serine protease that releases N-terminal dipeptides. It i...
A database of potentially biologically active peptide sequences, named BIOPEP (http://www.uwm.edu.pl...
An integrated approach combining liquid chromatography/tandem mass spectrometry (LC-MS/MS) with in s...
<p>Inhibition of dipeptidyl peptidase IV (DPP-IV) may be exploited to maintain the incretin effect d...
Inhibition of dipeptidyl peptidase IV (DPP-IV) may be exploited to maintain the incretin effect duri...
Inhibition of dipeptidyl peptidase IV (DPP-IV) may be exploited to maintain the incretin effect duri...
Molecular docking of a library of all 8000 possible tripeptides to the active site of DPP-IV was use...
BACKGROUND: There has been great interest in determining whether natural products show biological ac...
peer-reviewedBovine α-lactalbumin (α-La) contains numerous dipeptidyl peptidase IV (DPP-IV) inhibito...
Background: There has been great interest in determining whether natural products show biological ac...
Inhibition of the enzyme dipeptidyl-peptidase IV (DPP-IV) is a promising approach for managing hyper...
Dipeptidyl-peptidase IV (DPP-IV) plays an essential role in glucose metabolism by inactivating incre...
Dipeptidyl peptidase IV (DPP-IV) is a new molecular target correlated with the development of type 2...
The conventional approach in bioactive peptides discovery, which includes extensive bioassay-guided ...
Diabetes is a chronic metabolic disorder which leads to high blood sugar levels over a prolonged per...
Dipeptidyl peptidase IV (DPPIV, DPP4) is a serine protease that releases N-terminal dipeptides. It i...
A database of potentially biologically active peptide sequences, named BIOPEP (http://www.uwm.edu.pl...
An integrated approach combining liquid chromatography/tandem mass spectrometry (LC-MS/MS) with in s...