BIRC5 encodes the protein survivin, a member of the inhibitor of apoptosis family. Survivin is highly expressed in a variety of cancers but has very low expression in the corresponding normal tissues, and its expression is often associated with tumor metastasis and chemoresistance. We report that survivin was highly expressed in ovarian cancer and strongly correlated with patient overall poor survival. For the first time, we provide experimental evidence that survivin is involved in epithelial to mesenchymal transition (EMT) in ovarian cancer cells. Lentiviral CRISPR/Cas9 nickase vector mediated BIRC5 gene editing led to the inhibition of EMT by upregulating epithelial cell marker, cytokeratin 7 and downregulating mesenchymal markers: snail...
YM155 is an anti-cancer therapy that has advanced into 11 different human clinical trials to treat v...
[[abstract]]BIRC5/Survivin is known as a dual cellular functions protein that directly regulates bot...
AbstractObjectiveTo investigate the expression of survivin in breast cancer cell lines and explore t...
Survivin, a member of the inhibitor of apoptosis (IAP) family, is upregulated in multiple cancers in...
Ovarian cancer (OC) is the most lethal female gynecological malignancy, mostly due to diagnosis in l...
Merkel cell polyomavirus (MCV) causes ~80% of primary and metastatic Merkel cell carcinomas (MCCs). ...
Survivin, encoded by BIRC5 gene (baculoviral IAP repeat containing 5), belongs to the family of inhi...
Background: We previously reported that miR-203 functions as a tumor suppressor in ovarian cancer ce...
Abstract Background Survivin, belonging to the inhibitor of apoptosis (IAP) gene family, is abundant...
International audienceSurvivin overexpression, frequently found in breast cancers and others, is ass...
Survivin (BIRC5, product of the BIRC5 gene) is highly expressed in many tumor types and has been wid...
Colorectal cancer has provided an important model to test the stem cell hypothesis of cancer origin,...
Abnormalities in the control and execution of apoptosis are seen in many malignancies, including ova...
Survivin (BIRC5) promotes cell division and survival with roles as chromosomal passenger protein and...
BIRC5, also known as survivin, has been implicated in cell cycle progression and apoptosis avoidance...
YM155 is an anti-cancer therapy that has advanced into 11 different human clinical trials to treat v...
[[abstract]]BIRC5/Survivin is known as a dual cellular functions protein that directly regulates bot...
AbstractObjectiveTo investigate the expression of survivin in breast cancer cell lines and explore t...
Survivin, a member of the inhibitor of apoptosis (IAP) family, is upregulated in multiple cancers in...
Ovarian cancer (OC) is the most lethal female gynecological malignancy, mostly due to diagnosis in l...
Merkel cell polyomavirus (MCV) causes ~80% of primary and metastatic Merkel cell carcinomas (MCCs). ...
Survivin, encoded by BIRC5 gene (baculoviral IAP repeat containing 5), belongs to the family of inhi...
Background: We previously reported that miR-203 functions as a tumor suppressor in ovarian cancer ce...
Abstract Background Survivin, belonging to the inhibitor of apoptosis (IAP) gene family, is abundant...
International audienceSurvivin overexpression, frequently found in breast cancers and others, is ass...
Survivin (BIRC5, product of the BIRC5 gene) is highly expressed in many tumor types and has been wid...
Colorectal cancer has provided an important model to test the stem cell hypothesis of cancer origin,...
Abnormalities in the control and execution of apoptosis are seen in many malignancies, including ova...
Survivin (BIRC5) promotes cell division and survival with roles as chromosomal passenger protein and...
BIRC5, also known as survivin, has been implicated in cell cycle progression and apoptosis avoidance...
YM155 is an anti-cancer therapy that has advanced into 11 different human clinical trials to treat v...
[[abstract]]BIRC5/Survivin is known as a dual cellular functions protein that directly regulates bot...
AbstractObjectiveTo investigate the expression of survivin in breast cancer cell lines and explore t...