Triglycerides and cholesterol are essential for life in most organisms. Triglycerides serve as the principal energy storage depot and, where vascular systems exist, as a means of energy transport. Cholesterol is essential for the functional integrity of all cellular membrane systems. The endoplasmic reticulum is the site of secretory lipoprotein production and de novo cholesterol synthesis, yet little is known about how these activities are coordinated with each other or with the activity of the COPII machinery, which transports endoplasmic reticulum cargo to the Golgi. The Sar1B component of this machinery is mutated in chylomicron retention disorder, indicating that this Sar1 isoform secures delivery of dietary lipids into the circulation...
Background/Aims: Apolipoprotein E (apoE)-deficient mice develop hepatic steatosis and secrete reduce...
Apolipoprotein (apo) B is an obligatory component of triglyceride-rich lipoproteins. In the rare aut...
The endoplasmic reticulum (ER) serves as the entry point to the secretory system where nearly one-th...
Proteins and lipids are two major classes of transport cargos serving specific physiological functio...
Abstract Background Abnormal lipid metabolism may contribute to an increase in endoplasmic reticulum...
International audienceBackground-Understanding the specific mechanisms of rare autosomal disorders h...
Chylomicron metabolism plays a critical role in determining plasma levels of triacylglycerols (TAG) ...
Hepatic triacylglycerol levels are governed through synthesis, degradation and export of this lipid....
The liver maintains lipid homeostasis by regulating hepatic uptake of circulating fatty acids (FA) a...
Despite its importance for mammalian cell biology and human health, there are many basic aspects of ...
Vesicles that are coated by coat protein complex II (COPII) are the primary mediators of vesicular t...
Summary: Secretory cells produce diverse cargoes, yet how they regulate concomitant secretory traffi...
The key regulator of initial HDL particle formation by cells is the ATP-binding cassette transporter...
Abnormal distribution of cellular cholesterol is associated with numerous diseases, including cardio...
Plasma levels of high-density lipoproteins (HDL) and apolipoprotein A-I (apoA-I) are inversely corre...
Background/Aims: Apolipoprotein E (apoE)-deficient mice develop hepatic steatosis and secrete reduce...
Apolipoprotein (apo) B is an obligatory component of triglyceride-rich lipoproteins. In the rare aut...
The endoplasmic reticulum (ER) serves as the entry point to the secretory system where nearly one-th...
Proteins and lipids are two major classes of transport cargos serving specific physiological functio...
Abstract Background Abnormal lipid metabolism may contribute to an increase in endoplasmic reticulum...
International audienceBackground-Understanding the specific mechanisms of rare autosomal disorders h...
Chylomicron metabolism plays a critical role in determining plasma levels of triacylglycerols (TAG) ...
Hepatic triacylglycerol levels are governed through synthesis, degradation and export of this lipid....
The liver maintains lipid homeostasis by regulating hepatic uptake of circulating fatty acids (FA) a...
Despite its importance for mammalian cell biology and human health, there are many basic aspects of ...
Vesicles that are coated by coat protein complex II (COPII) are the primary mediators of vesicular t...
Summary: Secretory cells produce diverse cargoes, yet how they regulate concomitant secretory traffi...
The key regulator of initial HDL particle formation by cells is the ATP-binding cassette transporter...
Abnormal distribution of cellular cholesterol is associated with numerous diseases, including cardio...
Plasma levels of high-density lipoproteins (HDL) and apolipoprotein A-I (apoA-I) are inversely corre...
Background/Aims: Apolipoprotein E (apoE)-deficient mice develop hepatic steatosis and secrete reduce...
Apolipoprotein (apo) B is an obligatory component of triglyceride-rich lipoproteins. In the rare aut...
The endoplasmic reticulum (ER) serves as the entry point to the secretory system where nearly one-th...