Scavenger receptor classes A and B. Their roles in atherogenesis and the metabolism of modified LDL and HDL

van Berkel, T. J.
van Eck, M.
Herijgers, N.
Fluiter, K.
Nion, S.

Publication date

January 2000

Abstract

Scavenger-receptor class A has been held responsible for the clearance of modified LDL from the blood circulation. However, in mice deficient in scavenger-receptor class A, the decay in vivo of acetylated LDL (t1/2 <2 min), as well as tissue distribution and liver uptake (at 5 min 77.4 +/- 4.6% of the injected dose) are not significantly different from control mice. The degradation capacity of acetylated LDL with liver endothelial cells, Kupffer cells, and peritoneal macrophages from knock-out mice was 58%, 63%, and 17% of the control, respectively, indicating that scavenger-receptor class A is relatively more important for the degradation of acetylated LDL and foam cell formation in peritoneal macrophages as compared to the liver cell type...

Extracted data

We use cookies to provide a better user experience.

Data Protection

Scavenger receptor classes A and B. Their roles in atherogenesis and the metabolism of modified LDL and HDL

Abstract

Extracted data

Scavenger receptor classes A and B. Their roles in atherogenesis and the metabolism of modified LDL and HDL

Abstract

Extracted data

Related items

Related items