Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in either the TSC1 or TSC2 genes and characterized by developmental brain abnormalities. We defined the spectrum of brain abnormalities in fetal TSC brain ranging from 23 to 38 gestational weeks. We hypothesized (i) prenatal activation of the target-of-rapamycin complex 1 (TORC1) signaling pathway; and (ii) activation of inflammatory pathways in fetal brain lesions. Immunocytochemical analysis of cortical tubers, as well as subependymal lesions in all cases confirmed the cell-associated activation of the TORC1 signaling pathway in both the cortical tubers and subependymal lesions (including a congenital subependymal giant cell astrocytoma) with expression...
Mutations in the TSC1 and TSC2 genes cause tuberous sclerosis complex (TSC), a genetic disease often...
Tuberous sclerosis complex (TSC) is a multisystem developmental disorder caused by mutations in the ...
Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder that results form mutatio...
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in either the...
International audienceTuberous sclerosis (TSC) is a multisystem autosomal dominant genetic disorder ...
SummaryTuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by hamartoma...
Tuberous sclerosis complex is a dominantly inherited genetic disorder of striking clinical variabili...
Tuberous sclerosis complex (TSC), a heritable neurodevelopmental disorder, is caused by mutations in...
Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidit...
Tuberous sclerosis complex (TSC) is an autosomal-dominant neurocutaneous disorder with multi-organ i...
Tuberous sclerosis complex (TSC), a heritable neurodevelopmental disorder, is caused by mutations in...
Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder caused by mutations ...
Cortical tubers and subependymal giant cell tumors (SGCT) are two major cerebral. lesions associated...
Tuberous sclerosis complex (TSC) represents the prototypic monogenic disorder of the mammalian targe...
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by mutations in TSC...
Mutations in the TSC1 and TSC2 genes cause tuberous sclerosis complex (TSC), a genetic disease often...
Tuberous sclerosis complex (TSC) is a multisystem developmental disorder caused by mutations in the ...
Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder that results form mutatio...
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in either the...
International audienceTuberous sclerosis (TSC) is a multisystem autosomal dominant genetic disorder ...
SummaryTuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by hamartoma...
Tuberous sclerosis complex is a dominantly inherited genetic disorder of striking clinical variabili...
Tuberous sclerosis complex (TSC), a heritable neurodevelopmental disorder, is caused by mutations in...
Tuberous sclerosis complex (TSC) is a dominantly inherited disease with high penetrance and morbidit...
Tuberous sclerosis complex (TSC) is an autosomal-dominant neurocutaneous disorder with multi-organ i...
Tuberous sclerosis complex (TSC), a heritable neurodevelopmental disorder, is caused by mutations in...
Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder caused by mutations ...
Cortical tubers and subependymal giant cell tumors (SGCT) are two major cerebral. lesions associated...
Tuberous sclerosis complex (TSC) represents the prototypic monogenic disorder of the mammalian targe...
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by mutations in TSC...
Mutations in the TSC1 and TSC2 genes cause tuberous sclerosis complex (TSC), a genetic disease often...
Tuberous sclerosis complex (TSC) is a multisystem developmental disorder caused by mutations in the ...
Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder that results form mutatio...