Background Acute stress-induced hypersensitivity to colorectal distention was shown to depend on corticotropin releasing factor (CRF)-induced mast cell degranulation. At present it remains unclear whether CRF also induces chronic poststress activation of these cells. Accordingly, the objective of this study was to compare pre- and poststress CRF-receptor antagonist treatment protocols for their ability to, respectively, prevent and reverse mast cell dependent visceral hypersensitivity in a rat model of neonatal maternal separation. Methods The visceromotor response to colonic distention was assessed in adult maternally separated and non-handled rats before and at different time points after 1 h of water avoidance (WA). Rats were treated wit...
Multiple organs are targeted by the stress response, but the focus of this article is on stress-indu...
Multiple organs are targeted by the stress response, but the focus of this article is on stress-indu...
Functional gastrointestinal disorders (FGIDs) are characterized by dysregulated gut-brain interactio...
Visceral hypersensitivity is observed in the majority of patients with IBS and considered a pathophy...
Irritable bowel syndrome is in part characterized by an increased sensitivity to colonic distension....
Neonatal maternal deprivation (NMD) increases gut paracellular permeability (GPP) through mast cells...
Background: The histamine-1 receptor (H1R) antagonist ketotifen increased the threshold of discomfor...
BACKGROUND: The histamine-1 receptor (H1R) antagonist ketotifen increased the threshold of discomfor...
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related bo...
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related bo...
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related bo...
OBJECTIVES: Early life psychological stress is an essential factor contributing to the development o...
Visceral allodynia and increased colonic permeability are considered to be crucial pathophysiology o...
BACKGROUND AND AIM: Repeated water avoidance stress (WAS) induces visceral hypersensitivity. Additi...
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related bo...
Multiple organs are targeted by the stress response, but the focus of this article is on stress-indu...
Multiple organs are targeted by the stress response, but the focus of this article is on stress-indu...
Functional gastrointestinal disorders (FGIDs) are characterized by dysregulated gut-brain interactio...
Visceral hypersensitivity is observed in the majority of patients with IBS and considered a pathophy...
Irritable bowel syndrome is in part characterized by an increased sensitivity to colonic distension....
Neonatal maternal deprivation (NMD) increases gut paracellular permeability (GPP) through mast cells...
Background: The histamine-1 receptor (H1R) antagonist ketotifen increased the threshold of discomfor...
BACKGROUND: The histamine-1 receptor (H1R) antagonist ketotifen increased the threshold of discomfor...
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related bo...
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related bo...
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related bo...
OBJECTIVES: Early life psychological stress is an essential factor contributing to the development o...
Visceral allodynia and increased colonic permeability are considered to be crucial pathophysiology o...
BACKGROUND AND AIM: Repeated water avoidance stress (WAS) induces visceral hypersensitivity. Additi...
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related bo...
Multiple organs are targeted by the stress response, but the focus of this article is on stress-indu...
Multiple organs are targeted by the stress response, but the focus of this article is on stress-indu...
Functional gastrointestinal disorders (FGIDs) are characterized by dysregulated gut-brain interactio...