T cell differentiation in the thymus is characterized by a hierarchical order of rearrangement steps in the T cell receptor (TCR) genes, resulting in the joining of V, D, and J gene segments. During each of the rearrangement steps, DNA fragments between rearranging V, D, and J gene segments are deleted as circular excision products, the so-called TRECs (T cell receptor excision circles). TRECs are assumed to have a high over-time stability, but they can not multiply and consequently are diluted during T cell proliferation. It was recently suggested that quantitative detection of TRECs would allow for direct measurement of thymic output. The deltaRec-psiJalpha TREC appears to be the best marker, because the majority of thymocyte expansion oc...
When the TCR is formed in the thymus, fragments of DNA are excised from the T cell progenitor chromo...
Assessment of thymic output by measurement of naive T cells is carried out routinely in clinical dia...
The evaluation of human de novo T cell production is critical for a better understanding of T cell ...
Although the thymus constitutes a target organ for most protein and steroid hormones, it has been qu...
The human thymus exports newly generated T cells to the periphery. As no markers have been identifie...
The human thymus exports newly generated T cells to the periphery. As no markers have been identified...
Recent advances in characterizing thymic function confirm the importance of thymus to T-cell diversi...
Allogeneic hematopoietic stem cell transplantation (HSCT) is a well-established treatment modality f...
Currently, phenotypic markers that distinguish between recent thymic emigrants/de novo T cells and t...
T-cell receptor excision circles (TRECs) are circular DNA molecules formed during rearrangement of t...
AbstractThe thymus contributes naïve, self MHC reactive, self tolerant T cells to the peripheral imm...
T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) a...
The extent and rapidity with which T cells are regenerated from graft-derived precur-sor cells direc...
7 páginas, 3 figuras, 1 tabla.Current techniques to peripherally assess thymic function are: the sig...
Understanding T cell homeostasis requires knowledge of the export rate of new T cells from the thymu...
When the TCR is formed in the thymus, fragments of DNA are excised from the T cell progenitor chromo...
Assessment of thymic output by measurement of naive T cells is carried out routinely in clinical dia...
The evaluation of human de novo T cell production is critical for a better understanding of T cell ...
Although the thymus constitutes a target organ for most protein and steroid hormones, it has been qu...
The human thymus exports newly generated T cells to the periphery. As no markers have been identifie...
The human thymus exports newly generated T cells to the periphery. As no markers have been identified...
Recent advances in characterizing thymic function confirm the importance of thymus to T-cell diversi...
Allogeneic hematopoietic stem cell transplantation (HSCT) is a well-established treatment modality f...
Currently, phenotypic markers that distinguish between recent thymic emigrants/de novo T cells and t...
T-cell receptor excision circles (TRECs) are circular DNA molecules formed during rearrangement of t...
AbstractThe thymus contributes naïve, self MHC reactive, self tolerant T cells to the peripheral imm...
T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) a...
The extent and rapidity with which T cells are regenerated from graft-derived precur-sor cells direc...
7 páginas, 3 figuras, 1 tabla.Current techniques to peripherally assess thymic function are: the sig...
Understanding T cell homeostasis requires knowledge of the export rate of new T cells from the thymu...
When the TCR is formed in the thymus, fragments of DNA are excised from the T cell progenitor chromo...
Assessment of thymic output by measurement of naive T cells is carried out routinely in clinical dia...
The evaluation of human de novo T cell production is critical for a better understanding of T cell ...