BACKGROUND: Lentiviral gene transfer can provide long-term expression of therapeutic genes such as erythropoietin. Because overexpression of erythropoietin can be toxic, regulated expression is needed. Doxycycline inducible vectors can regulate expression of therapeutic transgenes efficiently. However, because they express an immunogenic transactivator (rtTA), their utility for gene therapy is limited. In addition to immunogenic proteins that are expressed from inducible vectors, injection of the vector itself is likely to elicit an immune response because viral capsid proteins will induce "danger signals" that trigger an innate response and recruit inflammatory cells. METHODOLOGY AND PRINCIPAL FINDINGS: We have developed an autoregulatory ...
Lentiviral vectors, originally derived from human immunodeficiency virus, provide highly efficient v...
Lentiviral vectors (LVs) are promising tools for in vivo gene delivery, either to correct genetic de...
Background: The in vivo transfer of naked plasmid DNA into organs such as muscles is commonly used t...
BACKGROUND: Lentiviral gene transfer can provide long-term expression of therapeutic genes such as e...
BACKGROUND: Lentiviral gene transfer can provide long-term expression of therapeutic genes such as e...
Gene therapy is a powerful approach to promote spinal cord regeneration. For a clinical application ...
A lentivirus pseudotyped with vesicular stomatitis virus G protein (VSV-G) encoding rat erythropoiet...
International audienceWe reported previously that controlled expression of a foreign gene in respons...
Recombinant erythropoietin (EPO) is widely administered for long-term treatment of anemia associated...
BACKGROUND: The in vivo transfer of naked plasmid DNA into organs such as muscles is commonly used t...
BackgroundTowards gene therapy treatment of patients with neutropenia, characterized by neutrophil c...
Stable gene replacement by in vivo administration of lentiviral vectors (LVs) has therapeutic potent...
Preclinical arterial gene transfer studies with adenoviral vectors are typically performed in labora...
Ligand-regulatable erythropoietin production by plasmid injection and in vivo electroporation.Backgr...
Viral vector-mediated gene transfer of neurotrophic factors is an emerging and promising strategy to...
Lentiviral vectors, originally derived from human immunodeficiency virus, provide highly efficient v...
Lentiviral vectors (LVs) are promising tools for in vivo gene delivery, either to correct genetic de...
Background: The in vivo transfer of naked plasmid DNA into organs such as muscles is commonly used t...
BACKGROUND: Lentiviral gene transfer can provide long-term expression of therapeutic genes such as e...
BACKGROUND: Lentiviral gene transfer can provide long-term expression of therapeutic genes such as e...
Gene therapy is a powerful approach to promote spinal cord regeneration. For a clinical application ...
A lentivirus pseudotyped with vesicular stomatitis virus G protein (VSV-G) encoding rat erythropoiet...
International audienceWe reported previously that controlled expression of a foreign gene in respons...
Recombinant erythropoietin (EPO) is widely administered for long-term treatment of anemia associated...
BACKGROUND: The in vivo transfer of naked plasmid DNA into organs such as muscles is commonly used t...
BackgroundTowards gene therapy treatment of patients with neutropenia, characterized by neutrophil c...
Stable gene replacement by in vivo administration of lentiviral vectors (LVs) has therapeutic potent...
Preclinical arterial gene transfer studies with adenoviral vectors are typically performed in labora...
Ligand-regulatable erythropoietin production by plasmid injection and in vivo electroporation.Backgr...
Viral vector-mediated gene transfer of neurotrophic factors is an emerging and promising strategy to...
Lentiviral vectors, originally derived from human immunodeficiency virus, provide highly efficient v...
Lentiviral vectors (LVs) are promising tools for in vivo gene delivery, either to correct genetic de...
Background: The in vivo transfer of naked plasmid DNA into organs such as muscles is commonly used t...