Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease
- Brand, Oliver J.
- Barrett, Jeffrey C.
- Simmonds, Matthew J.
- Newby, Paul R.
- McCabe, Christopher J.
- Bruce, Christopher K.
- Kysela, Boris
- Carr-Smith, Jackie D.
- Brix, Thomas
- Hunt, Penny J.
- Wiersinga, Wilmar M.
- Hegedus, Laszlo
- Connell, John
- Wass, John A. H.
- Franklyn, Jayne A.
- Weetman, Anthony P.
- Heward, Joanne M.
- Gough, Stephen C. L.
DOIAbstract
Graves' disease (GD) is a common autoimmune disease (AID) that shares many of its susceptibility loci with other AIDs. The thyroid stimulating hormone receptor (TSHR) represents the primary autoantigen in GD, in which autoantibodies bind to the receptor and mimic its ligand, thyroid stimulating hormone (TSH), causing the characteristic clinical phenotype. Although early studies investigating the TSHR and GD proved inconclusive, more recently we provided convincing evidence for association of the TSHR region with disease. In the current study we investigated a combined panel of 98 SNPs, including 70 tag SNPs, across an extended 800Kb region of the TSHR to refine association in a cohort of 768 GD subjects and 768 matched controls. In total 28...
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