Association between serum albumin and mortality in dialysis patients is partly explained by inflammation, and not by malnutrition
- de Mutsert, Renée
- Grootendorst, Diana C.
- Indemans, Fleur
- Boeschoten, Elisabeth W.
- Krediet, Raymond T.
- Dekker, Friedo W.
DOIAbstract
OBJECTIVE: We investigated the effects of inflammatory and nutritional status on the association between serum albumin and mortality in hemodialysis (HD) and peritoneal dialysis (PD) patients. DESIGN AND PATIENTS: This was a prospective cohort study of incident dialysis patients starting HD or PD. Inflammation (C-reactive protein >or=5 or >or=10 mg/L), malnutrition (1 to 5 on the 7-point subjective global assessment [SGA]), and low protein intake (normalized protein equivalent of nitrogen appearance [nPNA] <0.99 g/kg/day) were measured at 3 months after the start of dialysis. SETTING: The study involved 38 dialysis centers in The Netherlands. MAIN OUTCOME MEASURE: We ascertained all-cause mortality during the first 2 years after the start o...
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