Two-year efficacy and safety of Simvastatin 80 mg in familial hypercholesterolemia (The examination of probands and relatives in statin studies with familial hypercholesterolemia [ExPRESS FH])
- de Sauvage Nolting, Pernette R. W.
- Buirma, Rudolf J. A.
- Hutten, Barbara A.
- Kastelein, John J. P.
DOIAbstract
High-dose (80 mg) simvastatin is efficacious in both reducing low-density lipoprotein cholesterol (-48%) and triglyceride (-26%) levels and in elevating high-density lipoprotein cholesterol (+ 13%) levels in a large cohort of patients with familial hypercholesterolemia. No tachyphylaxis was seen during a 2-year treatment period, and therapy with simvastatin 80 mg was well tolerate
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