Follicular lymphoma international prognostic index

Solal-Céligny, Philippe
Roy, Pascal
Colombat, Philippe
White, Josephine
Armitage, Jim O.
Arranz-Saez, Reyes
Au, Wing Y.
Bellei, Monica
Brice, Pauline
Caballero, Dolores
Coiffier, Bertrand
Conde-Garcia, Eulogio
Doyen, Chantal
Federico, Massimo
Fisher, Richard I.
Garcia-Conde, Javier F.
Guglielmi, Cesare
Hagenbeek, Anton
Haïoun, Corinne
LeBlanc, Michael
Lister, Andrew T.
Lopez-Guillermo, Armando
McLaughlin, Peter
Milpied, Noël
Morel, Pierre
Mounier, Nicolas
Proctor, Stephen J.
Rohatiner, Ama
Smith, Paul
Soubeyran, Pierre
Tilly, Hervé
Vitolo, Umberto
Zinzani, Pier-Luigi
Zucca, Emanuele
Montserrat, Emili

Open link

Publication date

January 2004

DOI

10.1182/blood-2003-12-4434

Publisher

American Society of Hematology

Abstract

The prognosis of follicular lymphomas (FL) is heterogeneous and numerous treatments may be proposed. A validated prognostic index (PI) would help in evaluating and choosing these treatments. Characteristics at diagnosis were collected from 4167 patients with FL diagnosed between 1985 and 1992. Univariate and multivariate analyses were used to propose a PI. This index was then tested on 919 patients. Five adverse prognostic factors were selected: age (> 60 years vs or = 120 g/L), number of nodal areas (> 4 vs or = 3 adverse factors, 27% of patients, HR = 4.3). This Follicular Lymphoma International Prognostic Index (FLIPI) appeared more discriminant than the International Prognostic Index proposed for aggressive non-Hodgkin lymphomas. Resu...