Melanin synthesis is an oxygen-dependent process that acts as a potential source of reactive oxygen species (ROS) inside pigment-forming cells. The synthesis of the lighter variant of melanin, pheomelanin, consumes cysteine and this may limit the capacity of the cellular antioxidative defense. We show that tyrosine-induced melanogenesis in cultured normal human melanocytes (NHM) is accompanied by increased production of ROS and decreased concentration of intracellular glutathione. Clinical atypical (dysplastic) nevi (DN) regularly contain more melanin than do normal melanocytes (MC). We also show that in these cultured DN cells three out of four exhibit elevated synthesis of pheomelanin and this is accompanied by their early senescence. By ...
NOReactive oxygen species (ROS) such as hydrogen peroxide (H2O2) are produced in the skin under the ...
In order to evaluate the free radical defense systems of melanocytes and their possible correlation ...
Reactive oxygen species (ROS) such as hydrogen peroxide (H 2O2) are produced in the skin under the i...
We have recently reported a potential alternative tumor suppressor function for p16 relating to its ...
The question of whether melanins are photoprotecting and/or photosensitizing in human skin cells con...
Highly pigmented, dark skin is more resistant to the harmful effects of solar ultraviolet radiation ...
Melanoma cells, in comparison to normal melanocytes, contain higher concentrations of redox active s...
Melanins have been associated with the development of melanoma and its resistance to photodynamic th...
Melanins are ubiquitous catecholic pigments, formed in organelles called melanosomes within melanocy...
AbstractMelanins have been associated with the development of melanoma and its resistance to photody...
Melanoma has traditionally been viewed as an ultraviolet (UV) radiation-induced malignancy. While UV...
We have previously shown an imbalance of the antioxidant system in some cultures of normal melanocyt...
Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state...
International audienceKeratinocytes and melanocytes, two cutaneous cell types located within the epi...
The goal of this investigation was to correlate the melanin content in human pigmentary cells with t...
NOReactive oxygen species (ROS) such as hydrogen peroxide (H2O2) are produced in the skin under the ...
In order to evaluate the free radical defense systems of melanocytes and their possible correlation ...
Reactive oxygen species (ROS) such as hydrogen peroxide (H 2O2) are produced in the skin under the i...
We have recently reported a potential alternative tumor suppressor function for p16 relating to its ...
The question of whether melanins are photoprotecting and/or photosensitizing in human skin cells con...
Highly pigmented, dark skin is more resistant to the harmful effects of solar ultraviolet radiation ...
Melanoma cells, in comparison to normal melanocytes, contain higher concentrations of redox active s...
Melanins have been associated with the development of melanoma and its resistance to photodynamic th...
Melanins are ubiquitous catecholic pigments, formed in organelles called melanosomes within melanocy...
AbstractMelanins have been associated with the development of melanoma and its resistance to photody...
Melanoma has traditionally been viewed as an ultraviolet (UV) radiation-induced malignancy. While UV...
We have previously shown an imbalance of the antioxidant system in some cultures of normal melanocyt...
Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state...
International audienceKeratinocytes and melanocytes, two cutaneous cell types located within the epi...
The goal of this investigation was to correlate the melanin content in human pigmentary cells with t...
NOReactive oxygen species (ROS) such as hydrogen peroxide (H2O2) are produced in the skin under the ...
In order to evaluate the free radical defense systems of melanocytes and their possible correlation ...
Reactive oxygen species (ROS) such as hydrogen peroxide (H 2O2) are produced in the skin under the i...