The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study.
- Bosco, P.
- Redolfi, A.
- Bocchetta, M.
- Ferrari, C.
- Mega, A.
- Galluzzi, S.
- Austin, M.
- Chincarini, A.
- Collins, D.L.
- Duchesne, S.
- Maréchal, B.
- Roche, A.
- Sensi, F.
- Wolz, R.
- Alegret, M.
- Assal, F.
- Balasa, M.
- Bastin, C.
- Bougea, A.
- Emek-Savaş, D.D.
- Engelborghs, S.
- Grimmer, T.
- Grosu, G.
- Kramberger, M.G.
- Lawlor, B.
- Mandic Stojmenovic, G.
- Marinescu, M.
- Mecocci, P.
- Molinuevo, J.L.
- Morais, R.
- Niemantsverdriet, E.
- Nobili, F.
- Ntovas, K.
- O'Dwyer, S.
- Paraskevas, G.P.
- Pelini, L.
- Picco, A.
- Salmon, E.
- Santana, I.
- Sotolongo-Grau, O.
- Spiru, L.
- Stefanova, E.
- Popovic, K.S.
- Tsolaki, M.
- Yener, G.G.
- Zekry, D.
- Frisoni, G.B.
DOIAbstract
Hippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear. Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini-Mental State Examination ≥20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed. An increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of -8.0% (95% credible interval: [-11.5, -5.0]). Automate...
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