Iron-Catalysed Markovnikov Hydrothiolation of Styrenes

The bis(triflimide)iron(III) salt catalyzes the hydrothiolation of styrenes in a Markovnikov fashion with good selectivities and high yields. After isolation, different benzylic thioethers are obtained. This iron(III) catalyst is unique in terms of regioselectivity and represents a sustainable and economic alternative to those processes based on stoichiometric reagents.The work have been supported by Consolider-Ingenio 2010 (proyecto MULTICAT), and PROMETEO from Generalitat Valenciana. J.R.C.-A. thanks MCIINN for the provision of a doctoral grant. A.L.-P. thanks ITQ for financial support. We thank Dr. M. Domine for the HR-MS measurements.Cabrero Antonino, JR.; Leyva Perez, A.; Corma Canós, A. (2012). Iron-Catalysed Markovnikov Hydrothiolation of Styrenes. Advanced Synthesis and Catalysis. 354:678-687. doi:10.1002/adsc.201100731S678687354DAEMMRICH, A. A., & BOWDEN, M. E. (2005). PHARMA SINCE 1870. Chemical & Engineering News Archive, 83(25), 28-42. doi:10.1021/cen-v083n025.p028Page, P. 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