Coupling two multistep catalytic cycles for the one-pot synthesis of propargylamines from alcohols and primary amines on nanoparticulated gold catalyst

[EN] A one-pot reaction was performed with a nanoparticulated gold catalyst. A secondary amine is formed through N-monoalkylation of a primary amine with an alcohol by a borrowing hydrogen methodology in a three-step reaction. The secondary amine formed enters into a second A3-coupling cycle to give propargylamines. The multistep reaction requires a gold species formed and stabilized on a ceria surface.Financial support by the Direccion General de Investigacion Cientifica y Tecnica of Spain (Projects Consolider-Ingenio 2009 MIYCIN (CSD2009-00050) and MAT2011-28009).Corma Canós, A.; Navas Escrig, J.; Sabater Picot, MJ. (2012). Coupling two multistep catalytic cycles for the one-pot synthesis of propargylamines from alcohols and primary amines on nanoparticulated gold catalyst. Chemistry - A European Journal. 18(44):14150-14156. https://doi.org/10.1002/chem.201201837S1415014156184