BACKGROUND: Reduced plasma tryptophan occurs in depression and somatization. Induction of indoleamine 2,3-dioxygenase (IDO) with consequent synthesis of tryptophan catabolites (TRYCATs) and lowered tryptophan are associated with the onset of depression in the puerperium and during interferon-alpha treatment. Depression is accompanied by lowered kynurenic acid, a neuroprotectant, or increased kynurenine, a neurotoxic TRYCAT. AIMS AND METHODS: To examine plasma tryptophan; kynurenine; kynurenic acid; the kynurenine / tryptophan (KY/TRP) ratio, indicating IDO activity; and the kynurenine / kynurenic acid (KY/KA) ratio, indicating kynurenine aminotransferase (KAT) activity, in somatization; depression; somatization + depression; and controls. I...
The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. Th...
Introduction Bipolar disorder (BD) is a chronic psychiatric disease which can take most different a...
Obesity and depression are among the most pressing health problems in the contemporary world. Obesit...
A recent study comparing those with depression, somatization, comorbid depression + somatization, an...
Background: Tryptophan catabolites (“TRYCATs”) produced by the kynurenine pathway (KP) may play a ro...
Depression is highly prevalent worldwide and the leading cause of disability. It is believed that cu...
Background Several studies have suggested that induced tryptophan (TRP) degradation through the kynu...
Major depressive disorder (MDD) and bipolar disorder (BD) with melancholia and psychotic features an...
Background: Tryptophan catabolites ("TRYCATs") produced by the kynurenine pathway (KP) may play a ro...
BACKGROUND: Some previous studies found decreased concentrations of L-tryptophan (TRY) and increased...
It has been suggested that the metabolic enzyme indoleamine 2,3-dioxygenase (IDO) is a biological me...
There are circumferential evidences that major depression is associated with mild pro-inflammatory s...
Background: Tryptophan catabolites ("TRYCATs") produced by the kynurenine pathway (KP) may play a ro...
OBJECTIVE: Several somatic illnesses are associated with psychiatric comorbidity. Evidence is provid...
The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. Th...
Introduction Bipolar disorder (BD) is a chronic psychiatric disease which can take most different a...
Obesity and depression are among the most pressing health problems in the contemporary world. Obesit...
A recent study comparing those with depression, somatization, comorbid depression + somatization, an...
Background: Tryptophan catabolites (“TRYCATs”) produced by the kynurenine pathway (KP) may play a ro...
Depression is highly prevalent worldwide and the leading cause of disability. It is believed that cu...
Background Several studies have suggested that induced tryptophan (TRP) degradation through the kynu...
Major depressive disorder (MDD) and bipolar disorder (BD) with melancholia and psychotic features an...
Background: Tryptophan catabolites ("TRYCATs") produced by the kynurenine pathway (KP) may play a ro...
BACKGROUND: Some previous studies found decreased concentrations of L-tryptophan (TRY) and increased...
It has been suggested that the metabolic enzyme indoleamine 2,3-dioxygenase (IDO) is a biological me...
There are circumferential evidences that major depression is associated with mild pro-inflammatory s...
Background: Tryptophan catabolites ("TRYCATs") produced by the kynurenine pathway (KP) may play a ro...
OBJECTIVE: Several somatic illnesses are associated with psychiatric comorbidity. Evidence is provid...
The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. Th...
Introduction Bipolar disorder (BD) is a chronic psychiatric disease which can take most different a...
Obesity and depression are among the most pressing health problems in the contemporary world. Obesit...