Elevated striatal dopamine function linked to prodromal signs of schizophrenia
- Howes, Oliver D
- Montgomery, Andrew J
- Asselin, Marie-Claude
- Murray, Robin M
- Valli, Isabel
- Tabraham, Paul
- Bramon-Bosch, Elvira
- Valmaggia, Lucia
- Johns, Louise
- Broome, Matthew R.
- McGuire, Philip K
- Grasby, Paul M
Publication date
January 2009
DOI Publisher
American Medical Association (AMA)Abstract
These findings indicate that dopamine overactivity predates the onset of schizophrenia in individuals with prodromal psychotic symptoms, is predominantly localized in the associative striatum, and is correlated with the severity of symptoms and neurocognitive dysfunction
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