In Vitro and In Vivo Behaviour of I111n Complexes of TTHA, TTHA-Bis(Butylamide) and TTHA-Bis(Glucamide): Stability, Biodistribution and Excretion Studied by Gamma Imaging

Aiming at radiopharmaceutical application, I111n3+ complexes of the polyaminocarboxylates TTHA, TTHA-bis(butylamide) and TTHA-bis(glucamide) were investigated. The in vitro stability of I111n(TTHA)3- and I111n(TTHA-bis(butylamide)- was evaluated by measuring the exchange of I111n3+ from the complexes to transferrin and the results were compared with those for I111n(DTPA)2-. We also performed biodistribution studies of the three I111n3+ complexes by gamma-imaging in Wistar rats and by measuring the radioactivity in their organs. TTHA and its derivatives seem to have similar in vivo biodistribution with prevailing renal excretion.Applied Science