Add to ORKGWhat happens when your DNA breaks? This thesis describes experimental work on the single-molecule level focusing on the interaction between DNA and DNA-repair proteins, in particular bacterial RecA and human Rad51, involved in homologous recombination. Homologous recombination and its central event of DNA strand exchange are essential processes in all living organisms for generating genetic diversity and for repairing potentially disastrous DNA breaks. Several cancer-prone genetic diseases are associated with homologous recombination dysfunction or deficiency. With the use of single-molecule techniques like magnetic tweezers and atomic force microscopy, the complex mechanism of the DNA repair pathway of homologous recombination is slowly un...
Homologous recombination is an essential pathway in the repair of DNA damage during the DNA replicat...
Homologous Recombination (HR) is the only means by which the deadliest form of DNA damage (Double St...
As the average cell’s DNA undergoes roughly 1 million molecular lesions per day, learning about one ...
What happens when your DNA breaks? This thesis describes experimental work on the single-molecule le...
All organisms need homologous recombination (HR) to repair DNA double-strand breaks. Defects in reco...
All organisms need homologous recombination (HR) to repair DNA double-strand breaks. Defects in reco...
The repair of DNA double-strand breaks by homologous recombination is a high-fidelity pathway critic...
Homologous recombination, the exchange of strands between different DNA molecules, is essential for ...
Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for genomic inte...
textabstractChanges in our hereditary information are welcome in terms of generating diversity and d...
DNA inside a cell is continuously damaged through multiple mechanisms including environmental exposu...
The RccA protein of Escherichia coli mediates ho-mologous pairing and strand exchange reactions imi-...
DNA damage can be caused by external factors, or simply during replication. If such damage is not fi...
Recombinational repair is a well conserved DNA repair mechanism present in all living organisms. Rep...
Recombinational repair is a well conserved DNA repair mechanism present in all living organisms. Rep...
Homologous recombination is an essential pathway in the repair of DNA damage during the DNA replicat...
Homologous Recombination (HR) is the only means by which the deadliest form of DNA damage (Double St...
As the average cell’s DNA undergoes roughly 1 million molecular lesions per day, learning about one ...
What happens when your DNA breaks? This thesis describes experimental work on the single-molecule le...
All organisms need homologous recombination (HR) to repair DNA double-strand breaks. Defects in reco...
All organisms need homologous recombination (HR) to repair DNA double-strand breaks. Defects in reco...
The repair of DNA double-strand breaks by homologous recombination is a high-fidelity pathway critic...
Homologous recombination, the exchange of strands between different DNA molecules, is essential for ...
Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for genomic inte...
textabstractChanges in our hereditary information are welcome in terms of generating diversity and d...
DNA inside a cell is continuously damaged through multiple mechanisms including environmental exposu...
The RccA protein of Escherichia coli mediates ho-mologous pairing and strand exchange reactions imi-...
DNA damage can be caused by external factors, or simply during replication. If such damage is not fi...
Recombinational repair is a well conserved DNA repair mechanism present in all living organisms. Rep...
Recombinational repair is a well conserved DNA repair mechanism present in all living organisms. Rep...
Homologous recombination is an essential pathway in the repair of DNA damage during the DNA replicat...
Homologous Recombination (HR) is the only means by which the deadliest form of DNA damage (Double St...
As the average cell’s DNA undergoes roughly 1 million molecular lesions per day, learning about one ...