In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

Tosin, Manuela
Demydchuk, Yuliya
Parascandolo, James S.
Blasco Per, Covadonga
Leeper, F. J. (Finian J.)
Leadlay, P. F.

Publication date

January 2011

DOI

10.1039/c0cc05077f

Publisher

Royal Society of Chemistry (RSC)

ISSN

1359-7345

Abstract

Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters

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In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

Abstract

Extracted data

In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

Abstract

Extracted data

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