Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex
- Shnyder, Steve D.
- Fu, Y. (Ying)
- Habtemariam, Abraha
- Rijt, Sabine H. van
- Cooper, Patricia A.
- Loadman, Paul M.
- Sadler, P. J.
Publication date
July 2011
DOI Publisher
Royal Society of Chemistry (RSC) ISSN
2040-2503 Language
EnglishAbstract
This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(eta(6)-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF(6), is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine
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