Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi
- Bell, David J.
- Wootton, Daniel G.
- Mukaka, Mavuto
- Montgomery, Jacqui
- Kayange, Noel
- Chimpeni, Phillips
- Hughes, Dyfrig
- Molyneux, Malcolm E.
- Ward, Steve A.
- Winstanley, Peter
- Lalloo, David G.
Publication date
August 2009
DOI Publisher
Springer Science and Business Media LLC Language
EnglishAbstract
Sulphadoxine-pyrimethamine (SP) is the only single dose therapy for uncomplicated malaria, but there is widespread resistance. At the time of this study, artemether-lumefantrine (AL) and chlorproguanil-dapsone (CPD), both multi-dose regimes, were considered possible alternatives to SP in Malawi. The aim of this study was to investigate the impact of poor adherence on the effectiveness of AL and CPD
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