Neuregulins in the nucleus

The neuregulins are a subset of the ligands for the epidermal growth factor receptor family of receptors. They can bind to these receptors and evoke a range of cellular responses. Some of the neuregulins have however been found in the cell nucleus associated with nucleoli and intrachromatin granules. This brief review summarises the data for nuclear expression obtained from observations on normal and malignant tissues and the various laboratory experiments conducted to explore the system. Finally, we discuss the possible functions that could result from intra-nuclear expression of these molecules