The aim of the study is to verify the hypothesis that genetic polymorphisms are associated with the predisposition to all malignancies. Using as a model breast cancers from the homogenous Polish population (West Pomeranian region) after stratification of 977 patients by age at diagnosis (under 51 years and above 50 years) and by tumour pathology (ductal cancers––low and high grade, lobular cancers, ER-positive/negative) we tested this hypothesis. Altogether 20 different groups of breast cancer cases have been analyzed. The results were compared to a group of unaffected controls that were matched by age, sex, ethnicity and geographical location and originated from families without cancers of any site among relatives. Molecular alterations se...
Approximately 5–10% of all breast cancer cases are considered to be hereditary. BRCA1 and BRCA2 gene...
Breast cancer is one of the most common cancers in the world. The incidence in Malta is around 94 pe...
Breast cancer is a malignancy with a strong heritable component. Genetic counseling has been princip...
Abstract Objectives This study was undertaken to determine: 1) Type and prevalence of founder mutati...
Objectives: This study was undertaken to determine: 1) Type and prevalence of founder mutations BRCA...
It is a known fact that cancer risk is influenced by both environmental and genetic factors. Paramet...
There are twenty recurrent mutations in six breast-cancer-predisposing genes in Poland (BRCA1, BRCA2...
This study was aimed to assess the genetic determinants of the breast tumors. There was shown that g...
Breast cancer is one of the most frequently diagnosed cancers in the Western world and a significant...
PurposeTo determine the contribution of germline pathogenic variants (PVs) in hereditary cancer test...
The known breast cancer susceptibility genes only account for 20 % to 25 % of the excess familial ri...
While it has long been recognized that a proportion of breast cancer cases are the result of an inhe...
The thesis The analysis of genetic factors of breast cancer by NGS deals with the current serious pr...
Published by Laurien Van Dijckmmunosuppression plays a pivotal role in assisting tumors to evade imm...
Risks for breast cancer when there is a family history of the disease are usually calculated using d...
Approximately 5–10% of all breast cancer cases are considered to be hereditary. BRCA1 and BRCA2 gene...
Breast cancer is one of the most common cancers in the world. The incidence in Malta is around 94 pe...
Breast cancer is a malignancy with a strong heritable component. Genetic counseling has been princip...
Abstract Objectives This study was undertaken to determine: 1) Type and prevalence of founder mutati...
Objectives: This study was undertaken to determine: 1) Type and prevalence of founder mutations BRCA...
It is a known fact that cancer risk is influenced by both environmental and genetic factors. Paramet...
There are twenty recurrent mutations in six breast-cancer-predisposing genes in Poland (BRCA1, BRCA2...
This study was aimed to assess the genetic determinants of the breast tumors. There was shown that g...
Breast cancer is one of the most frequently diagnosed cancers in the Western world and a significant...
PurposeTo determine the contribution of germline pathogenic variants (PVs) in hereditary cancer test...
The known breast cancer susceptibility genes only account for 20 % to 25 % of the excess familial ri...
While it has long been recognized that a proportion of breast cancer cases are the result of an inhe...
The thesis The analysis of genetic factors of breast cancer by NGS deals with the current serious pr...
Published by Laurien Van Dijckmmunosuppression plays a pivotal role in assisting tumors to evade imm...
Risks for breast cancer when there is a family history of the disease are usually calculated using d...
Approximately 5–10% of all breast cancer cases are considered to be hereditary. BRCA1 and BRCA2 gene...
Breast cancer is one of the most common cancers in the world. The incidence in Malta is around 94 pe...
Breast cancer is a malignancy with a strong heritable component. Genetic counseling has been princip...