Familial association of laryngeal, lung, stomach and early-onset breast cancer
- Jaworowska, Ewa
- Serrano-Fernandez, Pablo
- Lubinski, Jan
- Tarnowska, Czeslawa
- Lubinski, Jakub
- Brzosko, Marek
- Flicinski, Jacek
- Masojc, Bartolomej
- Matyjasik, Joanna
- Scott, Rodney J.
- Narod, Steven A.
DOIAbstract
This study analyzes the incidence of different types of cancer among 2839 first-degree relatives of 760 consecutive, unselected laryngeal cancer patients, compared with the general population. A statistically significant excess was seen for other cancers of the larynx (SIR: 400), lung (SIR: 135) and stomach (SIR: 271), and early-onset breast cancer (SIR: 287). Familial laryngeal cancer may not be a single site-specific cancer syndrome
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