Prion diseases are a group of fatal neurodegenerative disorders that manifest as infectious, sporadic, or familial and are all associated with the misfolding of the prion protein (PrP). Disease-modulating polymorphisms in the PrP amino acid sequence can make an individual more or less susceptible to infection. One example is the presence of arginine in place of glutamine at position 171 in sheep, which confers resistance to scrapie. To investigate whether the physical folding properties of PrP arc influenced by the presence of arginine at codon 171, we have introduced the Mutation at the equivalent position (codon 167) in recombinant mouse PrP. We have then compared the unfolding properties of wild-type PrP and the Q167R mutant by monitorin...
When prions are transmitted between species, there can be a delay in pathogenesis due to a phenomeno...
When prions are transmitted between species, there can be a delay in pathogenesis due to a phenomeno...
Prion diseases are fatal neurodegenerative disorders characterized by misfolding of the cellular pri...
UNLABELLED: Prion diseases are a group of fatal and incurable neurodegenerative diseases affecting b...
Prions are responsible for a heterogeneous group of fatal neurodegenerative diseases, involving post...
Conformational change in the prion protein (PrP) is thought to be responsible for a group of rare bu...
Prion diseases are fatal neurodegenerative disorders characterized by misfolding of the cellular pri...
Conformational change in the prion protein (PrP) is thought to be responsible for a group of rare bu...
A key molecular event in prion diseases is the conversion of the cellular conformation of the prion ...
Prion diseases are a group of fatal and incurable neurodegenerative diseases affecting both humans a...
Prion diseases are a group of fatal neurodegenerative disorders that include Creutzfeldt-Jakob Disea...
Prion diseases, a group of incurable, lethal neurodegenerative disorders of mammals including humans...
Prion diseases are a group of fatal neurodegenerative disorders that include Creutzfeldt-Jakob Disea...
The β2–α2 loop of PrPC is a key modulator of disease-associated prion protein misfolding. Amino acid...
Prion diseases or transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative ...
When prions are transmitted between species, there can be a delay in pathogenesis due to a phenomeno...
When prions are transmitted between species, there can be a delay in pathogenesis due to a phenomeno...
Prion diseases are fatal neurodegenerative disorders characterized by misfolding of the cellular pri...
UNLABELLED: Prion diseases are a group of fatal and incurable neurodegenerative diseases affecting b...
Prions are responsible for a heterogeneous group of fatal neurodegenerative diseases, involving post...
Conformational change in the prion protein (PrP) is thought to be responsible for a group of rare bu...
Prion diseases are fatal neurodegenerative disorders characterized by misfolding of the cellular pri...
Conformational change in the prion protein (PrP) is thought to be responsible for a group of rare bu...
A key molecular event in prion diseases is the conversion of the cellular conformation of the prion ...
Prion diseases are a group of fatal and incurable neurodegenerative diseases affecting both humans a...
Prion diseases are a group of fatal neurodegenerative disorders that include Creutzfeldt-Jakob Disea...
Prion diseases, a group of incurable, lethal neurodegenerative disorders of mammals including humans...
Prion diseases are a group of fatal neurodegenerative disorders that include Creutzfeldt-Jakob Disea...
The β2–α2 loop of PrPC is a key modulator of disease-associated prion protein misfolding. Amino acid...
Prion diseases or transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative ...
When prions are transmitted between species, there can be a delay in pathogenesis due to a phenomeno...
When prions are transmitted between species, there can be a delay in pathogenesis due to a phenomeno...
Prion diseases are fatal neurodegenerative disorders characterized by misfolding of the cellular pri...